Malvidin induces hepatic stellate cell apoptosis via the endoplasmic reticulum stress pathway and mitochondrial pathway
文献类型： 外文期刊
作者： Ma, Yanhong 1 ; Li, Yahui 1 ; Zhang, Hongzhi 1 ; Wang, Ying 1 ; Wu, Caie 3 ; Huang, Wuyang 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, 50 Zhongling St, Nanjing 210014, Peoples R China
2.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Jiangsu, Peoples R China
3.Nanjing Forestry Univ, Coll Light Ind & Food Engn, Nanjing, Peoples R China
4.Jiangsu Acad Agr Sci, Jiangsu Key Lab Hort Crop Genet Improvement, Nanjing, Peoples R China
关键词： apoptosis; endoplasmic reticulum stress; hepatic stellate cells; malvidin; mitochondrial pathways
期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：2.863； 五年影响因子：3.141 ）
ISSN： 2048-7177
年卷期： 2020 年 8 卷 9 期
页码：
收录情况： SCI
摘要： Blueberries have great beneficial effects due to high level of anthocyanins, especially malvidin. Hepatic stellate cells (HSCs) can be activated and increase excessive extracellular matrix (ECM) components, which play a central role in liver fibrogenesis. Therefore, activated HSC's apoptosis can be induced to recover liver fibrosis. Malvidin's effects on apoptosis in rat activated hepatic stellate T6 cells (HSC-T6) in vitro were investigated here. High concentration of malvidin was found to significantly induce apoptosis, activate caspase-3, increase malondialdehyde, upregulate Bax, but downregulate Bcl-2. Moreover, malvidin upregulated the protein levels of some endoplasmic reticulum stress (ERS)-typical markers, including caspase-12, glucose-regulated protein 78 (GRP78), and CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP), suggesting that malvidin induced HSC apoptosis by the ERS apoptosis pathway as well as the mitochondrial-dependent pathway. These findings indicated that blueberry anthocyanins, especially malvidin, could induce activated hepatic stellate cell apoptosis and might act as one kind of functional food ingredient or a novel nutraceutical beneficial for liver health.
- 相关文献
作者其他论文 更多>>
-
Multiscale pore drives mechanical properties and storage stability in peach crisps
作者：Zhao, Han;Zhang, Bo;Xiang, Kexin;Li, Dajing;Liu, Chunju;Niu, Liying;Ma, Yanhong;Xiao, Yadong;Zhao, Han;Zhang, Bo;Xiang, Kexin;Liu, Chunju;Wang, Haiou;Liu, Chunju
关键词：Peach; Micro/nanopore structure; Pore distribution; Mechanical properties; Storage stability
-
Analysis of the effect of three different blanching processes on the flavor profile of peeled and unpeeled broad beans
作者：Shi, Lu;Fu, Xiaohui;Lin, Menghua;Li, Yahui;Liang, Ying;Zhang, Zhiyong;Fu, Xiaohui
关键词：Broad bean; Blanching; HS-GC-IMS; Volatile compounds; Antioxidant activity
-
Hyaluronic acid-decorated lipid nanocarriers as novel vehicles for curcumin: Improved stability, cellular absorption, and anti-inflammatory effects
作者：Feng, Jin;Wang, Zhen;Huang, Wuyang;Zhao, Xingyu;Xu, Lujing;Teng, Cong;Li, Ying;Wang, Zhen;Zhao, Xingyu
关键词：Nanostructured lipid carriers; Hyaluronic acid; Curcumin; Oral delivery; Receptor-mediated endocytosis; Anti-inflammatory capacity
-
Optimization of Ultrasonic-Enzymatic-Assisted Extraction of Flavonoids from Sea Buckthorn (Hippophae rhamnoides L.) Pomace: Chemical Composition and Biological Activities
作者：Suo, Wenyu;Suo, Wenyu;Wang, Wenzhe;Li, Dajing;Wu, Haihong;Huang, Wuyang;Ma, Yanhong;Liu, Haiyan
关键词：
Hippophae rhamnoides L.; flavonoids; ultrasonic-enzymatic-assisted extraction; antioxidant; alpha-glucosidase and alpha-amylase inhibition -
Comparative analysis of lipid profiles and aroma characteristics in pecan oils: Probing conventional and non-conventional extraction techniques
作者：Cui, Jingtao;Zhang, Tao;Jiang, Xinchen;Qian, Yaming;Zhu, Haijun;Cui, Li;Huang, Wuyang;Cui, Jingtao
关键词：Pecan oil; Extraction techniques; Foodomics analysis; Lipid profile; Volatile compound
-
Synergism between TLR4 and B. infantis in the development of the premature intestine
作者：Huang, Wuyang;Huang, Wuyang;Djebali, Karim;Cho, Ky Young;Gardner, Kimberly;Fasano, Alessio;Meng, Di;Walker, W. Allan;Djebali, Karim;Cho, Ky Young;Gardner, Kimberly
关键词：
-
Interpenetrating network hydrogels loaded with nanostructured lipid carriers for curcumin delivery: Impact of dual crosslinking with genipin and calcium ions
作者：Feng, Jin;Liu, Dian;Wang, Zhen;Li, Chunyang;Huang, Wuyang;Li, Ying;Wang, Zhen;Liu, Songbai
关键词：Interpenetrating network hydrogels; Curcumin; Rheological properties; Intermolecular forces; Controlled release; Bioavailability
