Pre-protective effect of polysaccharides purified from Hericium erinaceus against ethanol-induced gastric mucosal injury in rats
文献类型： 外文期刊
作者： Chen, Wanchao 1 ; Wu, Di 1 ; Jin, Yueling 2 ; Li, Qiaozhen 1 ; Liu, Yanfang 1 ; Qiao, Xuxin 2 ; Zhang, Jingsong 1 ; Dong, 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Natl Engn Res Ctr Edible Fungi, Key Lab Edible Fungi Resources & Utilizat South, Inst Edible Fungi,Minist Agr, Shanghai 201403, Peoples R China
2.Shanghai Univ Med & Hlth Sci, Shanghai 200237, Peoples R China
关键词： Hericium erinaceus; Purified polysaccharide; Gastroprotective activity; Gastric ulcer
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）
ISSN： 0141-8130
年卷期： 2020 年 159 卷
页码：
收录情况： SCI
摘要： The beta-glucan H6PC20 (Mw: 2390 kDa) and alpha-heteropolysaccharide HPB-3 (Mw: 15 kDa) were purified from the fruiting body of Hericium erinaceus according to the previous methods. Their gastroprotective activities and corresponding structure-activity relationship were studied in the ethanol-induced gastric ulcer model of rats. After intragastric administrated with H6PC20 and HPB-3 for 14 days, macroscopic and histological evaluation of gastric mucosa was improved significantly. The defense and repair factors (EGF, bFGF and PGE(2)) were increased, mean-while, the inflammatory cytokines (IL-1 beta and TNF-alpha) and MDA were reduced. These results indicated that H6PC20 and HPB-3 presented gastroprotective activities with the mechanism of activating repair and defense system, decreasing the inflammatory response and alleviating the oxidative injury. Furthermore, the structure-activity relationship showed that the macromolecular beta-glucan was better for repair and defense system, while the low weight molecular alpha-heteropolysaccharide focused on the anti-inflammatory effect. The polysac-charides purified from H. erinaceus can be developed as a potential gastroprotective ingredient for applications in pharmaceutical field. (C) 2020 Published by Elsevier B.V.
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