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Exploration of Susceptible Genes with Clustered Regularly Interspaced Short Palindromic Repeats-Tissue-Specific Knockout (CRISPR-TSKO) to Enhance Host Resistance

文献类型： 外文期刊

作者： Moniruzzaman, M. 1 ; Yun Zhong 1 ; Yan, Huaxue 2 ; Lv Yuanda 3 ; Bo Jiang 1 ; Zhong, Guangyan 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Fruit Tree Res, 80,Dafeng 2nd St, Guangzhou 510640, Peoples R China

2.Minist Agr, Key Lab South Subtrop Fruit Biol & Genet Resource, Guangzhou, Peoples R China

3.Sci & Technol Dept Guangdong Prov, Key Lab Trop & Subtrop Fruit Tree Res, Guangzhou, Peoples R China

关键词： CRISPR-TSKO; disease resistance; durable immunity; genome editing; Huanglongbing; susceptible gene

期刊名称：CRITICAL REVIEWS IN PLANT SCIENCES （ 影响因子：5.188； 五年影响因子：9.148 ）

ISSN： 0735-2689

年卷期： 2020 年 39 卷 5 期

页码：

收录情况： SCI

摘要： Susceptible (S) genes are those plant genes that facilitate pathogen infection and disease. The loss of function of these genes primarily interrupts the growth and development of invading pathogens and thus makes plants resistant. TheS-gene-targeted resistance may produce durable immunity in plants. Because,Sgene-based resistance is derived from the inactivation of a host factor required for the survival of a pathogen in the host. To bypass theSgene-based resistance, a parasitic pathogen must evolve and develop the same or similar functions provided naturally by its host factors, which is far more difficult or even may be impossible. However, it is critical to identify and target the appropriateSgene(s) aiming to gain resistant capacity against a particular disease, becauseSgenes may be pathogen-specific in many cases. The clustered regularly interspaced short palindromic repeats (CRISPR) technology has shown great potential in manipulatingSgenes in plants. The CRISPR-TSKO (CRISPR-based tissue-specific knock-out) tool kit can provide an understanding of the exact function of an individual gene in a tissue and developmental stage-specific manner while also producing a heritable mutant allele. In this review, candidateSgenes have been summarized for CRISPR-TSKO mediated tissue-specific gene knockdown to enhance host resistance.

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