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The protective effect of rosmarinic acid on myotube formation during myoblast differentiation under heat stress

文献类型： 外文期刊

作者： Chen, Kun-Lin 1 ; Wang, Yue 2 ; Lin, Zhi-Ping 3 ; Li, Hui-Xia 2 ;

作者机构： 1.Jiangsu Acad Agr Sci, Minist Sci & Technol, Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base, Nanjing 210014, Peoples R China

2.Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Peoples R China

3.Youyuan Res Inst Dairy Ind Co Ltd, Nanjing 211100, Peoples R China

关键词： Heat stress; Rosmarinic acid; Apoptosis; Myotube formation; Myoblast differentiation

期刊名称：IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL （ 影响因子：2.416； 五年影响因子：2.117 ）

ISSN： 1071-2690

年卷期： 2020 年 56 卷 8 期

页码：

收录情况： SCI

摘要： High ambient temperature is one of the most important environmental factors that caused the reduction of livestock productivity and the increase of mortality. It has been shown that heat stress could affect the meat quality characteristics by physiological and metabolic perturbations in live livestock. Rosmarinic acid (RA) is a natural polyphenolic phytochemical compound that has many important biological activities, such as antioxidant, antimutagenic, and antitumor. The purpose of this study was to investigate the possible function and mechanism of RA on myoblast proliferation and differentiation under heat stress condition. The results showed that heat stress reduced the viability of myoblast and increased the percentage of apoptotic cells, and it also disrupted myotube formation by altering the expression of myogenic regulatory factors MyoD, myogenin, and MyHC. However, pretreatment of RA can protect C2C12 cells from heat stress-induced apoptosis, and it also increased the expression level of MyoD, myogenin, and MyHC under heat stress, which indicated that RA have protective effect on heat stress-caused failure of myotube formation during myoblast differentiation. Above all, our finding demonstrated that RA can promote the differentiation of C2C12 myoblast and maintain the formation of myotubes even under heat stress condition.

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