Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism
文献类型： 外文期刊
作者： He, Jin 1 ; Zhang, Peiwen 1 ; Shen, Linyuan 1 ; Niu, Lili 1 ; Tan, Ya 1 ; Chen, Lei 1 ; Zhao, Ye 1 ; Bai, Lin 1 ; Hao, Xiaox 1 ;
作者机构： 1.Sichuan Agr Univ, Coll Anim Sci & Technol, Chengdu 611130, Peoples R China
2.Sichuan Agr Univ, Farm Anim Genet Resource Explorat & Innovat Key L, Chengdu 611130, Peoples R China
3.Guizhou Acad Agr Sci, Inst Anim Husb & Vet, Guiyang 550005, Peoples R China
关键词： short-chain fatty acids; inflammation; glycose and lipid metabolism; signalling pathways
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 2020影响因子：5.923； 五年影响因子：6.132 ）
年卷期： 2020 年 21 卷 17 期
收录情况： SCI
摘要： Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly produced by anaerobic fermentation of gut microbes. SCFAs play an important role in regulating energy metabolism and energy supply, as well as maintaining the homeostasis of the intestinal environment. In recent years, many studies have shown that SCFAs demonstrate physiologically beneficial effects, and the signalling pathways related to SCFA production, absorption, metabolism, and intestinal effects have been discovered. Two major signalling pathways concerning SCFAs, G-protein-coupled receptors (GPRCs) and histone deacetylases (HDACs), are well recognized. In this review, we summarize the recent advances concerning the biological properties of SCFAs and the signalling pathways in inflammation and glucose and lipid metabolism.
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