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Napthrene Compounds from Mycelial Fermentation Products ofMarasmius berteroi

文献类型： 外文期刊

作者： Yang, Ning Ning 1 ; Yun, Qing 1 ; Kong, Fan Dong 1 ; Xie, Qing Yi 1 ; Dai, Hao Fu 1 ; Zhou, Li Man 1 ; Yu, Zhi Fang 4 ; Z 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China

2.Bengbu Univ, Coll Food & Bioengn, Bengbu 233030, Peoples R China

3.Chinese Acad Trop Agr Sci, Hainan Inst Trop Agr Resources, Haikou 571101, Hainan, Peoples R China

4.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Peoples R China

关键词： Marasmius berteroi; dipolynaphthalenes; binapthrene; AChE inhibitory activity; cytotoxic activity

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN：

年卷期： 2020 年 25 卷 17 期

页码：

收录情况： SCI

摘要： The metabolites of the genusMarasmiusare diverse, showing good research prospects for finding new bioactive molecules. In order to explore the active metabolites of the fungiMarasmius berteroi, the deep chemical investigation on the bioactive compounds from its cultures was undertaken, which led to the isolation of three new naphthalene compounds dipolynaphthalenes A-B (1,2) and naphthone C (3), as well as 12 known compounds (4-15). Compounds1,2, and4are dimeric naphthalene compounds. Their structures were elucidated by MS, 1D and 2D NMR spectroscopic data, as well as ECD calculations. Compounds2-4and7exhibited acetylcholinesterase (AChE) inhibitory activities at the concentration of 50 mu g/mL with inhibition ratios of 42.74%, 44.63%, 39.50% and 51.49%, respectively. Compounds5and7,8showed weak inhibitory activities towards two tumor cell lines, with IC(50)of 0.10, 0.076 and 0.058 mM (K562) and 0.13, 0.18, and 0.15 mM (SGC-7901), respectively.

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