文献类型： 外文期刊
作者： Wang, Yuzhe 1 ; Bu, Lina 2 ; Cao, Xuemin 2 ; Qu, Hao 3 ; Zhang, Chunyuan 2 ; Ren, Jiangli 2 ; Huang, Zhuolin 2 ; Zhao, Yi 1 ;
作者机构： 1.China Agr Univ, Coll Anim Sci & Technol, Beijing, Peoples R China
2.China Agr Univ, Coll Biol Sci, State Key Lab Agrobiotechnol, Beijing, Peoples R China
3.Guangdong Acad Agr Sci, Inst Anim Sci, Guangdong Key Lab Anim Breeding & Nutr, State Key Lab Livestock & Poultry Breeding, Guangzhou, Peoples R China
关键词： chicken; advanced intercross line; bone growth; ancestral inference; QTL fine-mapping; genome-wide association study; selective sweep; haplotype association study
期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.599； 五年影响因子：4.888 ）
ISSN：
年卷期： 2020 年 11 卷
页码：
收录情况： SCI
摘要： The advanced intercross line (AIL) that is created by successive generations of pseudo-random mating after the F(2)generation is a valuable resource, especially in agricultural livestock and poultry species, because it improves the precision of quantitative trait loci (QTL) mapping compared with traditional association populations by introducing more recombination events. The growth traits of broilers have significant economic value in the chicken industry, and many QTLs affecting growth traits have been identified, especially on chromosomes 1, 4, and 27, albeit with large confidence intervals that potentially contain dozens of genes. To promote a better understanding of the underlying genetic architecture of growth trait differences, specifically body weight and bone development, in this study, we report a nine-generation AIL derived from two divergent outbred lines: High Quality chicken Line A (HQLA) and Huiyang Bearded (HB) chicken. We evaluate the genetic architecture of the F-0, F-2, F-8, and F(9)generations of AIL and demonstrate that the population of the F(9)generation sufficiently randomized the founder genomes and has the characteristics of rapid linkage disequilibrium decay, limited allele frequency decline, and abundant nucleotide diversity. This AIL yielded a much narrower QTL than the F(2)generations, especially the QTL on chromosome 27, which was reduced to 120 Kb. An ancestral haplotype association analysis showed that most of the dominant haplotypes are inherited from HQLA but with fluctuation of the effects between them. We highlight the important role of four candidate genes (PHOSPHO1,IGF2BP1,ZNF652, andGIP) in bone growth. We also retrieved a missing QTL from AIL on chromosome 4 by identifying the founder selection signatures, which are explained by the loss of association power that results from rare alleles. Our study provides a reasonable resource for detecting quantitative trait genes and tracking ancestor history and will facilitate our understanding of the genetic mechanisms underlying chicken bone growth.
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