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Coexistence of Antibiotic Resistance Genes and Virulence Factors Deciphered by Large-Scale Complete Genome Analysis

文献类型： 外文期刊

作者： Pan, Yu 1 ; Zeng, Jiaxiong 1 ; Li, Liguan 4 ; Yang, Jintao 3 ; Tang, Ziyun 3 ; Xiong, Wenguang 1 ; Li, Yafei 5 ; Chen, Sh 1 ;

作者机构： 1.South China Agr Univ, Guangdong Prov Key Lab Vet Drugs Dev & Safety Eva, Guangzhou, Peoples R China

2.South China Agr Univ, Natl Risk Assessment Lab Antimicrobial Resistance, Guangzhou, Peoples R China

3.Guangdong Lab Lingnan Modern Agr, Guangzhou, Peoples R China

4.Tech Univ Denmark, Dept Environm Engn, Lyngby, Denmark

5.Guangdong Acad Agr Sci, Publ Monitoring Ctr Agroprod, Guangzhou, Peoples R China

6.City Univ Hong Kong, Jockey Club Coll Vet Med & Life Sci, Dept Infect Dis & Publ Hlth, Kowloon, Hong Kong, Peoples R China

关键词： antibiotic resistance; virulence factors; gene coexistence; bacterial genome; pathogens; natural environment; public health risk

期刊名称：MSYSTEMS （ 影响因子：6.496； 五年影响因子：8.236 ）

ISSN： 2379-5077

年卷期： 2020 年 5 卷 3 期

页码：

收录情况： SCI

摘要： Widespread use of antibiotics has enhanced the evolution of highly resilient pathogens and poses a severe risk to human health via coselection of antibiotic resistance genes (ARGs) and virulence factors (VFs). In this study, we rigorously evaluate the abundance relationship and physical linkage between ARGs and VFs by performing a comprehensive analysis of 9,070 bacterial genomes isolated from multiple species and hosts. The coexistence of ARGs and VFs was observed in bacteria across distinct phyla, pathogenicities, and habitats, especially among human-associated pathogens. The coexistence patterns of gene elements in different habitats and pathogenicity groups were similar, presumably due to frequent gene transfer. A shorter intergenic distance between mobile genetic elements and ARGs/VFs was detected in human/animal-associated bacteria, indicating a higher transfer potential. Increased accumulation of exogenous ARGsNFs in human pathogens highlights the importance of gene acquisition in the evolution of human commensal bacteria. Overall, the findings provide insights into the genic features of combinations of ARG-VF and expand our understanding of ARG-VF coexistence in bacteria. IMPORTANCE Antibiotic resistance has become a serious global health concern. Despite numerous case studies, a comprehensive analysis of ARG and VF coexistence in bacteria is lacking. In this study, we explore the coexistence profiles of ARGs and VFs in diverse categories of bacteria by using a high-resolution bioinformatics approach. We also provide compelling evidence of unique ARG-VF gene pairs coexisting in specific bacterial genomes and reveal the potential risk associated with the coexistence of ARGs and VFs in organisms in both clinical settings and environments.

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