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Sulfadiazine pharmacokinetics in grass carp (Ctenopharyngodon idellus) receiving oral and intravenous administrations

文献类型： 外文期刊

作者： Xu, Ning 1 ; Fu, Yu 4 ; Chen, Fang 4 ; Liu, Yongtao 1 ; Dong, Jing 1 ; Yang, Yibin 1 ; Zhou, Shun 1 ; Yang, Qiuhong 1 ; Ai, 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, 8 Wuda Pk Rd 1, Wuhan 430223, Hubei, Peoples R China

2.Minist Agr, Key Lab Control Qual & Safety Aquat Prod, Beijing, Peoples R China

3.Hu Bei Prov Engn & Technol Res Ctr Aquat Prod Qua, Wuhan, Peoples R China

4.Hunan Univ Arts & Sci, Changde, Peoples R China

关键词： bioavailability; grass carp; pharmacokinetics; sulfadiazine

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 2020影响因子：1.786； 五年影响因子：1.7 ）

ISSN： 0140-7783

年卷期：

页码：

收录情况： SCI

摘要： This study aimed to examine the bioavailability (BA) and pharmacokinetic (PK) characteristics of sulfadiazine (SDZ) in grass carp (Ctenopharyngodon idellus) after oral and intravenous administrations. Blood samples were collected at predetermined time points of 0.083, 0.17, 0.5, 1, 2, 4, 8, 16, 24, 48, 72, and 96 hr (n = 6). The samples were extracted and purified by organic reagents and determined by the ultra-performance liquid chromatography. The software named 3P97 was used to calculate relevant PK parameters. The results demonstrated that the concentration-time profile of SDZ was best described by a one-compartmental open model with first-order absorption after a single oral dose. The main PK parameters of the absorption rate constant (K-alpha), the absorption half-life (t(1/2 K alpha)), the elimination rate constant (K-e), the elimination half-life (t(1/2Ke)), and the area under concentration-time profile (AUC(0-infinity)) were 0.3 1/h, 2.29 hr, 0.039 1/h, 17.64 hr, and 855.78 mg.h/L, respectively. Following intravenous administration, the concentration-time curve fitted to a two-compartmental open model without absorption. The primary PK parameters of the distribution rate constant (alpha), the elimination rate constant (beta), the distribution half-life (t(1/2 alpha)), the elimination half-life (t(1/2 beta)), the apparent distribution volume (V-SS), the total clearance (CL), and AUC(0-infinity)were 9.62 1/hr, 0.039 1/hr, 0.072 hr, 17.71 hr, 0.33 L/kg, 0.013 L h(-1) kg(-1), and 386.23 mg.h/L, respectively. Finally, the BA was calculated to be 22.16%. Overall, this study will provide some fundamental information on PK properties in the development of a new formulation SDZ in the future and is partially beneficial for the appropriate usage of SDZ in aquaculture.

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