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Analysis and Screening of Reproductive Long Non-coding RNAs Through Genome-Wide Analyses of Goat Endometrium During the Pre-attachment Phase

文献类型： 外文期刊

作者： Hong, Linjun 1 ; Hu, Qun 1 ; Zang, Xupeng 1 ; Xie, Yanshe 1 ; Zhou, Chen 1 ; Zou, Xian 1 ; Li, Yaokun 1 ; Deng, Ming 1 ; Guo 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangzhou, Peoples R China

2.Lingnan Guangdong Lab Modern Agr, Guangzhou, Peoples R China

3.Guangdong Acad Agr Sci, Guangdong Key Lab Anima Breeding & Nutr, State Key Lab Livestock & Poultry Breeding, Inst Anim Sci,Guangdong Publ Lab Anim Breeding &, Guangzhou, Peoples R China

关键词： RNA-seq; goat; endometrium; lncRNA; implantation

期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.599； 五年影响因子：4.888 ）

ISSN：

年卷期： 2020 年 11 卷

页码：

收录情况： SCI

摘要： Reproduction in goat is highly impeded by implantation failure. Of concern, the underlying mechanism leading to embryo implantation remains unclear. In this study, deep sequencing was employed through strand-specific Ribo-Zero RNA-Seq to characterize transcriptome changes in the endometrium during the maternal recognition of pregnancy. A total of 996 differential transcripts (115 lncRNAs and 881 mRNAs) existing between the pregnant and non-pregnant endometrium were revealed through bioinformatics analysis. The screening was performed on lncRNAs (XR_001918173.1, LNC_002760, and LNC_000599) and LNC_009053, to determine their potential role in regulating the synthesis of retinol and endometrium remolding through the proteasome pathway, respectively. The hypothesis of whether certain lncRNAs, namely, LNC_007223, LNC_005256, and LNC_010092 could play important roles in embryo implantation was tested. These novel findings are of paramount relevance to further elucidate the molecular mechanisms of embryo implantation and uncover new targets to improve goat reproduction.

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