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Association between the copy number variation of CCSER1 gene and growth traits in Chinese Capra hircus (goat) populations

文献类型： 外文期刊

作者： Xu, Zijie 1 ; Wang, Xianwei 3 ; Song, Xingya 1 ; An, Qingming 4 ; Wang, Dahui 4 ; Zhang, Zijing 5 ; Ding, Xiaoting 1 ; Yao, Zhi 1 ; Wang, Eryao 5 ; Liu, Xian 3 ; Ru, Baorui 3 ; Xu, Zejun 3 ; Huang, Yongzhen 1 ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China

2.Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Child, State Key Lab Biotherapy, Chengdu, Peoples R China

3.Henan Prov Anim Husb Gen Stn, Zhengzhou, Henan, Peoples R China

4.Tongren Univ, Coll Agr & Forestry Engn, Tongren, Guizhou, Peoples R China

5.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou, Henan, Peoples R China

关键词： CCSER1 gene; copy number variations; association analysis; growth traits; Capra hircus (goat)

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.141； 五年影响因子：1.92 ）

ISSN： 1049-5398

年卷期：

页码：

收录情况： SCI

摘要： Recently, Coiled-coil serine-rich protein 1 (CCSER1) gene is reported to be related to economic traits in livestock, and become a hotspot. In our study, we detected CCSER1 gene CNV in 693 goats from six breeds (GZB, GZW, AN, BH, HG, TH) by quantitative real-time PCR (qPCR) and the association analysis between the types of CNV and growth traits. Then, CCSER1 gene expression pattern was discovered in seven tissues from NB goats. Our results showed that the CCSER1 gene copy numbers were distributed differently in the aforementioned six breeds. The type of CCSER1 gene CNV was significantly associated with body weight and heart girth traits in GZW goat, in which individuals with deletion type were dominant in body weight trait (P < 0.05), while the normal type individuals were more advantageous in heart girth trait (P < 0.01); and there was a significant association with heart girth in TH goat (P < 0.05), which normal type was the dominant one. The expression profile revealed that CCSER1 gene has the highest level in the lung, followed by the small intestine and heart. In conclusion, our result is dedicated to an in-depth study of the novel CCSER1 gene CNV site and to provide essential information for Chinese goats molecular selective breeding in the future.

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