Electrochemically promoted annulation of aldehydes and carbazates: access to 2-alkoxy/aryloxy-5-substituted 1,3,4-oxadiazole and 1,3,4-oxadiazol-2(3H)-one derivatives
文献类型： 外文期刊
作者： Li, Hongjun 1 ; Tang, Dong 2 ; Iqbal, Zafar 2 ; Wan, Yaya 2 ; Jiang, Rui 2 ; Yang, Zhixiang 2 ; Yang, Jinhui 1 ;
作者机构： 1.Ningxia Univ, Coll Chem & Chem Engn, State Key Lab High Efficiency Utilizat Coal & Gre, Yinchuan 750021, Ningxia, Peoples R China
2.Ningxia Acad Agr & Forestry Sci, Agr Resource & Environm Inst, Ningxia Ctr Agr Organ Synth Agr, Yinchuan 750002, Ningxia, Peoples R China
期刊名称：NEW JOURNAL OF CHEMISTRY （ 影响因子：3.925； 五年影响因子：3.629 ）
ISSN： 1144-0546
年卷期： 2022 年 46 卷 42 期
页码：
收录情况： SCI
摘要： An efficient and eco-friendly synthesis of chemically and pharmaceutically interesting 2-alkoxy/aryloxy-1,3,4-oxadiazoles, and 1,3,4-oxadiazol-2(3H)-ones has been developed through the annulation of aldehydes and carbazates. The protocol involves electrochemically promoted access to the desired products in good to excellent yields. The method uses NaBr as an electrocatalyst, and MeOH as a solvent. The strategy is oxidant-free and transition-metal free, offering the electrolyte-free completion of the reaction at room temperature. A possible mechanism has been proposed based on control-experiment results and literature reports. The practical utility of this approach is highlighted via the brief synthesis of 5-(4-chloro-3-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one, which is a potent inhibitor of Notum carboxylesterase activity.
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