Palmatine Inhibits the Pathogenicity of Aeromonas hydrophila by Reducing Aerolysin Expression
文献类型： 外文期刊
作者： Dong, Jing 1 ; Yan, Tianhui 2 ; Yang, Qiuhong 1 ; Song, Yi 3 ; Cheng, Bo 3 ; Zhou, Shun 1 ; Liu, Yongtao 1 ; Ai, Xiaohui 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China
2.Bohai Univ, Coll Food Sci & Engn, Jinzhou 121013, Peoples R China
3.Chinese Acad Fishery Sci, Beijing 100039, Peoples R China
关键词： Aeromonas hydrophila; aerolysin; palmatine; anti-virulence; antibiotic resistance
期刊名称：FOODS （ 影响因子：5.561； 五年影响因子：5.94 ）
ISSN：
年卷期： 2022 年 11 卷 20 期
页码：
收录情况： SCI
摘要： Aeromonas hydrophila, an opportunistic aquatic pathogen widely spread in aquatic environments, is responsible for a number of infectious diseases in freshwater aquaculture. In addition, A. hydrophila can transmit from diseased fish to humans and results in health problems. The occurrence of antibiotic-resistant bacterial strains restricts the application of antibiotics and is responsible for failure of the treatment. Moreover, residues of antibiotics in aquatic products often threaten the quality and safety. Therefore, alternative strategies are called to deal with infections caused by antibiotic-resistant bacteria. Aerolysin, one of the most important virulence factors of A. hydrophila, is adopted as a unique anti-virulence target on the basis of the anti-virulence strategy to battling infections caused by A. hydrophila. Palmatine, an isoquinoline alkaloid from a variety of herbal medicines that showed no anti-A. hydrophila activity, could reduce hemolysis of the bacterium by decreasing aerolysin production. The results of the qPCR assay demonstrated that the transcription of the aerA gene was suppressed. Moreover, cell viability and in vivo study showed that palmatine treatment could decrease the pathogenicity of A. hydrophila both in vitro and in vivo. In summary, palmatine is a leading compound against A. hydrophila-associated infection in aquaculture by inhibiting the expression of aerolysin.
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