Effects of polysaccharides from Lyophyllum decastes (Fr.) Singer on gut microbiota via in vitro-simulated digestion and fermentation
文献类型： 外文期刊
作者： Zhang, Fangfang 1 ; Xiao, Ying 2 ; Pan, Liang 1 ; Yu, Ling 1 ; Liu, Yanfang 3 ; Li, Deshun 3 ; Liu, Xiaojie 2 ;
作者机构： 1.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai, Peoples R China
2.Shanghai Urban Construct Vocat Coll, Sch Hlth & Social Care, Shanghai, Peoples R China
3.Minist Agr & Rural Affairs, Natl Engn Res Ctr Edible Fungi, Key Lab Edible Fungi Resources & Utilizat South, Shanghai, Peoples R China
4.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai, Peoples R China
关键词： Lyophyllum decastes (Fr; ) Singer; polysaccharides; simulated digestion; fermentation; short-chain fatty acids
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）
ISSN：
年卷期： 2023 年 14 卷
页码：
收录情况： SCI
摘要： IntroductionLyophyllum decastes (Fr.) Singer polysaccharides (LDSPs) have been verified to possess strong biological properties. However, the effects of LDSPs on intestinal microbes and their metabolites have rarely been addressed. MethodsThe in vitro-simulated saliva-gastrointestinal digestion and human fecal fermentation were used to evaluate the effects of LDSPs on non-digestibility and intestinal microflora regulation in the present study. ResultsThe results showed a slight increase in the content of the reducing end of the polysaccharide chain and no obvious change in the molecular weight during in vitro digestion. After 24 h in vitro fermentation, LDSPs were degraded and utilized by human gut microbiota, and LDSPs could be transformed into short-chain fatty acids leading to significant (p < 0.05) decrease in the pH of the fermentation solution. The digestion did not remarkably affect the overall structure of LDSPs and 16S rRNA analysis revealed distinct shifts in the gut microbial composition and community diversity of the LDSPs-treated cultures, compared with the control group. Notably, the LDSPs group directed a targeted promotion of the abundance of butyrogenic bacteria, including Blautia, Roseburia, and Bacteroides, and an increase in the n-butyrate level. DiscussionThese findings suggest that LDSPs might be a potential prebiotic to provide a health benefit.
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