Identification and Expression Analysis of LncRNAs Reveal the Immune Mechanism of Visceral White-Nodules Disease Resistance in Large Yellow Croaker
文献类型： 外文期刊
作者： Bai, Yulin 1 ; Chen, Xintong 1 ; Qu, Ang 1 ; Liu, Yue 1 ; Zhao, Ji 1 ; Ke, Qiaozhen 1 ; Pu, Fei 1 ; Wu, Linni 1 ; Chi, Hongshu 3 ; Gong, Hui 3 ; Zhou, Tao 1 ; Xu, Peng 1 ;
作者机构： 1.Xiamen Univ, Coll Ocean & Earth Sci, Fujian Key Lab Genet & Breeding Marine Organisms, Xiamen 361102, Peoples R China
2.Ningde Fufa Fisheries Co Ltd, State Key Lab Large Yellow Croaker Breeding, Ningde 352130, Peoples R China
3.Fujian Acad Agr Sci, Biotechnol Inst, Fuzhou 350003, Peoples R China
4.Xiamen Univ, Coll Ocean & Earth Sci, State Key Lab Marine Environm Sci, Xiamen 361102, Peoples R China
关键词： Larimichthys crocea; Pseudomonas plecoglossicida; LncRNAs; Immune mechanism; Hub genes
期刊名称：MARINE BIOTECHNOLOGY （ 影响因子：3.727； 五年影响因子：3.782 ）
ISSN： 1436-2228
年卷期：
页码：
收录情况： SCI
摘要： Long non-coding RNAs (lncRNAs) have several known functions in fish growth processes and signal transduction, but their possible roles in response to bacterial diseases remain largely unresolved. In this study, we report a comprehensive cold-water bacterial disease-responsive lncRNA expression profile for understanding the transcriptional regulatory mechanisms of visceral white-nodules disease resistance in large yellow croaker. A total of 2534 high-confidence lncRNAs were identified by a rigorous filtering pipeline as a basic sequence set for comparative transcriptional analysis. In addition, a total of 10,200 lncRNA-mRNA pairs with high correlation coefficients were identified by expressions level correlation analysis, including non-redundant 381 DE lncRNAs and 2590 differential expressed genes. MSTRG_11084_1 and MSTRG_20402_1 were linked to a large number of target genes and may be involved in important functions in immune regulation. We further revealed the conserved and idiosyncratic features of the disease response process between the technical control strain (TCS) and the resistant strain (RS). Immune-related pathways were enriched in GO terms and KEGG pathways, among which cytokine-cytokine receptor interaction, MAPK signaling pathway, and NF-kappa B signaling pathway may play a key role in VWND resistance in large yellow croaker. Protein-protein interaction network (PPI) analysis revealed that immune-related target genes such as il-10, met, acta2, myc, cav1, and ntrk1, as well as growth and metabolism-related target genes such as pik3r2, igf1, sc5d, hmgcr, and lss were considered the main hub genes. This study represents the first characterization of lncRNAs involved in VWND resistance in large yellow croaker and provides new clues for elucidating the disease response mechanism of large yellow croaker.
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