Pickering emulsions constructed on the basis of nanostructured lipid carriers: Effect of carrier models and volume fractions
文献类型： 外文期刊
作者： Liu, Dian 1 ; Feng, Jin 1 ; Nasiru, Mustapha Muhammad 1 ; Zhang, Jing 1 ; Zhu, Hequan 3 ; Li, Chunyang 1 ; Xu, Cunfa 4 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, 50 Zhongling St, Nanjing 210014, Peoples R China
2.Fed Univ Dutsin Ma, Dept Food Sci & Technol, PMB 5001, Dutsin Ma, Katsina State, Nigeria
3.Chinese Acad Agr Sci, Inst Apicultural Res, Beijing, Peoples R China
4.Jiangsu Acad Agr Sci, Cent Lab, 50 Zhongling St, Nanjing 210014, Peoples R China
5.50 Zhongling St, Nanjing 210014, Peoples R China
关键词： Nanostructured lipid carriers; Pickering emulsions; Inversion; Stability; Simulated digestion
期刊名称：JOURNAL OF MOLECULAR LIQUIDS （ 2022影响因子：6.0； 五年影响因子：5.6 ）
ISSN： 0167-7322
年卷期： 2024 年 397 卷
收录情况： SCI
摘要： Three types of curcumin-loaded nanostructured lipid carriers with a single layer (S-NLCs), double layer (D-NLCs) and composite layer (C-NLCs) were used as stabilizers for the preparation of Pickering emulsions. Visual observations showed that the NLCs stabilized the Pickering emulsions at different addition volume fractions. The emulsions produced had approximate particle size and showed an inversion of the emulsions stabilized by DNLCs and C-NLCs as the additional fraction of NLCs was increased to 50%. Contact angles and interfacial viscoelasticity showed a better wetting of D-NLCs with a superior ability to reduce surface tension at the oil-water interface. Pickering emulsions stabilized at a 50% volume ratio (PD5) showed the highest storage and centrifugal stability. Simulated in vitro digestion studies showed the presence of delayed lipid digestion of Pickering emulsions, resulting in the incomplete release of curcumin and lower bioavailability than NLCs under the same conditions.
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