Anti-Inflammatory and Antioxidant Properties of beta-Sitosterol in Copper Sulfate-Induced Inflammation in Zebrafish (Danio rerio)
文献类型： 外文期刊
作者： Zhang, Peng 1 ; Liu, Naicheng 1 ; Xue, Mingyang 2 ; Zhang, Mengjie 1 ; Liu, Wei 2 ; Xu, Chen 2 ; Fan, Yuding 2 ; Meng, Yan 2 ; Zhang, Qinghua 1 ; Zhou, Yong 2 ;
作者机构： 1.Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China
2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China
3.Shanghai Ocean Univ, Natl Pathogen Collect Ctr Aquat Anim, Shanghai 201306, Peoples R China
关键词： beta-sitosterol; zebrafish (Danio rerio); oxidative stress; anti-inflammation; antioxidant
期刊名称：ANTIOXIDANTS （ 影响因子：7.0； 五年影响因子：7.3 ）
ISSN：
年卷期： 2023 年 12 卷 2 期
页码：
收录情况： SCI
摘要： beta-Sitosterol, which is used extensively in pharmaceuticals, nutraceuticals, and cosmetics, has high nutritional value along with immunomodulatory and anti-inflammatory properties. In this study, we investigated the antioxidant and anti-inflammatory effects of beta-sitosterol in zebrafish and explored the associated molecular mechanisms. In an in vivo antioxidant experiment, zebrafish (Danio rerio) larvae were treated with different concentrations of beta-sitosterol and then exposed to a nonlethal concentration of CuSO4 to induce oxidative stress. Treatment with beta-sitosterol at 70 or 100 mu g/mL significantly reduced CuSO4-induced oxidative stress in the zebrafish, demonstrating the strong antioxidant activity of beta-sitosterol. Treatment with beta-sitosterol protected zebrafish larvae against oxidative damage from CuSO4 by upregulating the expressions of sod and gpx4b. In a zebrafish model of inflammation, pretreatment with beta-sitosterol before CuSO4 exposure inhibited neutrophil recruitment and damage to lateral line neuromasts, indicating a potent anti-inflammatory effect derived from reductions in the expressions of il-8 and myd88. The results demonstrate the antioxidative and anti-inflammatory activities of beta-sitosterol and suggest that beta-sitosterol may be useful for the treatment of various inflammatory diseases.
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