T-2 toxin-induced intestinal damage with dysregulation of metabolism, redox homeostasis, inflammation, and apoptosis in chicks
文献类型： 外文期刊
作者： Liu, Meng 1 ; Zhao, Ling 1 ; Wei, Jin-Tao 1 ; Huang, Yu-Xuan 1 ; Khalil, Mahmoud Mohamed 3 ; Wu, Wen-Da 4 ; Kuca, Kamil 5 ; Sun, Lv-Hui 1 ;
作者机构： 1.Huazhong Agr Univ, Coll Anim Sci & Technol, Frontiers Sci Ctr Anim Breeding & Sustainable Prod, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China
2.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Wuhan 430064, Peoples R China
3.Massey Univ, Monogastr Res Ctr, Sch Agr & Environm, Palmerston North 4442, New Zealand
4.Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing, Peoples R China
5.Univ Hradec Kralove, Fac Sci, Dept Chem, Rokitanskeho 62, Hradec Kralove 50003, Czech Republic
关键词： T-2 toxin; Chicks; Intestine; Microbiome; Metabolome; Transcriptome
期刊名称：ARCHIVES OF TOXICOLOGY （ 影响因子：6.1； 五年影响因子：5.7 ）
ISSN： 0340-5761
年卷期： 2023 年
页码：
收录情况： SCI
摘要： T-2 toxin is a worldwide problem for feed and food safety, leading to livestock and human health risks. The objective of this study was to explore the mechanism of T-2 toxin-induced small intestine injury in broilers by integrating the advanced microbiomic, metabolomic and transcriptomic technologies. Four groups of 1-day-old male broilers (n = 4 cages/group, 6 birds/cage) were fed a control diet and control diet supplemented with T-2 toxin at 1.0, 3.0, and 6.0 mg/kg, respectively, for 2 weeks. Compared with the control, dietary T-2 toxin reduced feed intake, body weight gain, feed conversion ratio, and the apparent metabolic rates and induced histopathological lesions in the small intestine to varying degrees by different doses. Furthermore, the T-2 toxin decreased the activities of glutathione peroxidase, thioredoxin reductase and total antioxidant capacity but increased the concentrations of protein carbonyl and malondialdehyde in the duodenum in a dose-dependent manner. Moreover, the integrated microbiomic, metabolomic and transcriptomic analysis results revealed that the microbes, metabolites, and transcripts were primarily involved in the regulation of nucleotide and glycerophospholipid metabolism, redox homeostasis, inflammation, and apoptosis were related to the T-2 toxin-induced intestinal damage. In summary, the present study systematically elucidated the intestinal toxic mechanisms of T-2 toxin, which provides novel ideas to develop a detoxification strategy for T-2 toxin in animals.
- 相关文献
作者其他论文 更多>>
-
Hepatoprotective effects of dandelion against AFB1-induced liver injury are associated with activation of bile acid-FXR signaling in chicks
作者：Peng, Zhe;Xu, Ze-Jing;Niu, Qin-Jian;Dessalegn, Lamesgen;Refaie, Alainaa;Sun, Lv-Hui;Feng, Yan-Ping;Liu, Meng;Deng, Jiang
关键词：Dandelion; Aflatoxin B 1; Hepatotoxicity; Bile acids; FXR signaling; Chicks
-
Butyric acid-based products, alone or in combination with hydroxy-selenomethionine, improve performance of laying hens in post-peak period by modulating their antioxidant, metabolic and immune status
作者：Xia, Zhiyuan;Gong, Guoxin;Huang, Ronghui;Zhao, Ling;Wei, Jintao;Deng, Jiang;Goossens, Tim;Cardoso, Denise;Mallmann, Barbara;Lemale, Olga;Wei, Jintao
关键词：butyric acid; selenium; hen; laying performance; antioxidant
-
Five glutathione S-transferase isozymes played crucial role in the detoxification of aflatoxin B1 in chicken liver
作者：Deng, Jiang;Peng, Zhe;Xia, Zhiyuan;Mo, Yixin;Sun, Lvhui;Liu, Meng;Deng, Jiang;Guo, Lijia;Wei, Jintao
关键词：Aflatoxin B-1; Chicken; Detoxification; Enzymatic characteristics; GST isozymes
-
Loss of SELENOW aggravates muscle loss with regulation of protein synthesis and the ubiquitin-proteasome system
作者：Yang, Jia-Cheng;Liu, Meng;Huang, Rong-Hui;Zhao, Ling;Niu, Qin-Jian;Xu, Ze-Jing;Sun, Lv-Hui;Wei, Jin-Tao;Lei, Xin Gen
关键词：
-
Short-Chain Fatty Acids Alleviate Vancomycin-Caused Humoral Immunity Attenuation in Rabies-Vaccinated Mice by Promoting the Generation of Plasma Cells via Akt-mTOR Pathway
作者：Wu, Qiong;Zhang, Yachun;Wang, Caiqian;Hou, Yarong;He, Wenna;Wang, Lingli;Xiong, Jingyi;Ren, Zeheng;Wang, Haoran;Sui, Baokun;Zhou, Ming;Fu, Zhen F.;Zhao, Ling;Zhao, Ling;Zhao, Ling;Zhou, Danna;Zhou, Danna;Zhou, Danna
关键词：rabies vaccine; gut microbiome; SCFA; vancomycin; B cells; Akt-mTOR pathway
-
Resistin secreted by porcine alveolar macrophages leads to endothelial cell dysfunction during Haemophilus parasuis infection
作者：Hua, Kexin;He, Yanling;Guan, Aohan;Chen, Liying;Gao, Yuan;Xu, Qianshuan;Wang, Haoyu;Luo, Rui;Zhao, Ling;Jin, Hui;Hua, Kexin;He, Yanling;Guan, Aohan;Chen, Liying;Gao, Yuan;Xu, Qianshuan;Wang, Haoyu;Luo, Rui;Zhao, Ling;Jin, Hui;Hua, Kexin;He, Yanling;Guan, Aohan;Chen, Liying;Gao, Yuan;Xu, Qianshuan;Wang, Haoyu;Luo, Rui;Zhao, Ling;Jin, Hui;Li, Tingting
关键词：Haemophilus parasuis; resistin; tight junctions; LKB1; AMPK; mTOR pathway; outer membrane lipoprotein a; exudative inflammation
-
Mitigation Effects of Bentonite and Yeast Cell Wall Binders on AFB(1), DON, and OTA Induced Changes in Laying Hen Performance, Egg Quality, and Health
作者：Zhao, Ling;Feng, Yue;Zhu, Meng-Xiang;Zhang, Lei;Sun, Lv-Hui;Zhao, Ling;Feng, Yue;Sun, Lv-Hui;Wei, Jing-Tao;Zhang, Jia-Cai;Karrow, Niel Alexander;Han, Yan-Ming;Wu, Yuan-Yuan;Guo, Yu-Ming
关键词：mycotoxins; laying hens; performance; binder; remediation
