Characterization of H9N2 avian influenza virus isolated from chickens and waterfowl in parts of Southern China from 2018 to April 2024
文献类型： 外文期刊
作者： Zhou, Wanting 1 ; He, Jun 3 ; Qiao, Fangfang 1 ; Wang, Mengyao 1 ; Zeng, Qinghang 1 ; Liu, Yang 4 ; Zhao, Yue 3 ; Zhang, Liji 2 ; Li, Ting 2 ; Du, Shouwen 2 ; Sun, Minhua 2 ; Liao, Ming 1 ;
作者机构： 1.Zhong Kai Univ Agr & Engn, Coll Anim Sci & Technol, Guangzhou 510225, Peoples R China
2.Guangdong Acad Agr Sci, Guangdong Prov Key Lab Livestock Dis Prevent, Guangdong Prov Key Lab Prevent & Control Avian Inf, Inst Anim Hlth,Minist Agr & Rural Affairs, Guangzhou 510640, Peoples R China
3.Jinan Univ, Minist Educ, Inst Lab Anim Sci Prevent & Control, Guangzhou Key Lab Germ Free Anim & Microbiota Appl, Guangzhou 510632, Peoples R China
4.Guangzhou Med Univ, Guangzhou Inst Resp Hlth, State Key Lab Resp Dis, Natl Clin Res Ctr Resp Dis,Affiliated Hosp 1, Guangzhou 510120, Peoples R China
5.South China Normal Univ, Inst Ecol Sci, Guangzhou 510631, Peoples R China
6.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Peoples R China
关键词： Avian influenza; Biological characteristics; Epidemiological surveillance
期刊名称：POULTRY SCIENCE （ 影响因子：4.2； 五年影响因子：4.5 ）
ISSN： 0032-5791
年卷期： 2025 年 104 卷 10 期
页码：
收录情况： SCI
摘要： The H9N2 subtype of avian influenza virus (AIV) has become endemic in poultry farms across China, providing internal genes for other subtypes of viruses and occasionally having the ability to infect humans, thereby posing a significant public health threat. In this study, 61 H9N2 viruses were isolated from chickens and waterfowl in Southern China between 2018 and April 2024. We characterized their genetic derivation, antigenic diversity, receptor-binding specificity, neuraminidase (NA) activity, replication, and transmission in chickens and systematic pathological analysis. Genetic analysis revealed that 60 isolates belonged to the h9.4.2.5 lineage, while 7, 20, and 33 H9 strains belonged to the h9.4.2.5a, b, and c branches, respectively. One isolate belonged to the h9.4.2.1 lineage. Mainly tested H9N2 strains preferentially bound to human-type receptors, except one virus exhibiting dual receptor-binding specificity. Antigenicity analysis indicated that these tested viruses could be classified into 2 separate antigenic clusters. In addition, the selected viruses efficiently replicated and transmitted in chickens at a high dose induction. Continuous and systematic surveillance of H9N2 virus mutation and infection in poultry farms is crucial for early detection of novel recombinant viruses with pandemic potential and for enhancing biosecurity control.
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