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Hematopoietic Stem and Progenitor Cells (HSPCs) and Hematopoietic Microenvironment: Molecular and Bioinformatic Studies of the Zebrafish Models

文献类型： 外文期刊

作者： Faisal, Muhammad 1 ; Hassan, Mubashir 2 ; Kumar, Aman 3 ; Zubair, Muhammad 4 ; Jamal, Muhammad 5 ; Menghwar, Harish 6 ; Saad, Muhammad 7 ; Kloczkowski, Andrzej 2 ;

作者机构： 1.Ohio State Univ, Coll Med, Div Hematol, Comprehens Canc Ctr, Columbus, OH 43210 USA

2.Nationwide Childrens Hosp, Steve & Cindy Rasmussen Inst Genom Med, Res Inst, Columbus, OH 43205 USA

3.Ohio State Univ, Dept Ophthalmol & Vis Sci, Columbus, OH 43210 USA

4.Jiangsu Acad Agr Sci, Dept Vet Med, Nanjing 210014, Peoples R China

5.Wuhan Univ, Sch Basic Med Sci, Dept Immunol, Wuhan 430072, Peoples R China

6.Laval Univ, CHU Quebec Res Ctr CHUL, Axe Mol Endocrinol & Nephrol, Quebec City, PQ G1V 4G2, Canada

7.Ohio State Univ, Dept Anim Sci, Columbus, OH 43205 USA

8.Ohio State Univ, Dept Pediat, Columbus, OH 43205 USA

关键词： hematopoietic stem cells (HSCs); hematopoietic niche; hematopoietic microenvironment; zebrafish; RNA-binding proteins

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：6.208； 五年影响因子：6.628 ）

ISSN：

年卷期： 2022 年 23 卷 13 期

页码：

收录情况： SCI

摘要： Hematopoietic stem cells (HSCs) reside in a specialized microenvironment in a peculiar anatomic location which regulates the maintenance of stem cells and controls its functions. Recent scientific progress in experimental technologies have enabled the specific detection of epigenetic factors responsible for the maintenance and quiescence of the hematopoietic niche, which has improved our knowledge of regulatory mechanisms. The aberrant role of RNA-binding proteins and their impact on the disruption of stem cell biology have been reported by a number of recent studies. Despite recent modernization in hematopoietic microenvironment research avenues, our comprehension of the signaling mechanisms and interactive pathways responsible for integration of the hematopoietic niche is still limited. In the past few decades, zebrafish usage with regards to exploratory studies of the hematopoietic niche has expanded our knowledge for deeper understanding of novel cellular interactions. This review provides an update on the functional roles of different genetic and epigenetic factors and molecular signaling events at different sections of the hematopoietic microenvironment. The explorations of different molecular approaches and interventions of latest web-based tools being used are also outlined. This will help us to get more mechanistic insights and develop therapeutic options for the malignancies.

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