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Immunomagnetic separation for the enrichment of trace enrofloxacin and analysis of degradation byproducts in water

文献类型： 外文期刊

作者： Yang, Ruonan 1 ; Zhu, Lei 2 ; Gao, Yuxiao 2 ; Li, Bingzhi 1 ; Fang, Longxiang 3 ; Meng, Shunlong 2 ; Song, Chao 1 ;

作者机构： 1.Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210023, Peoples R China

2.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Peoples R China

3.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 214081, Peoples R China

4.Minist Agr & Rural Affairs, Lab Qual & Safety Risk Assessment Aquat Prod Envir, Wuxi 214081, Peoples R China

5.Minist Agr & Rural Affairs, Key Lab Control Qual & Safety Aquat Prod, Beijing 100000, Peoples R China

6.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resources, Minist Agr & Rural Affairs, Wuxi 214081, Peoples R China

关键词： degradation mechanisms; enrofloxacin; immunomagnetic separation; toxicity assessment; trace antibiotics

期刊名称：WATER REUSE （ 影响因子：3.3； 五年影响因子：3.6 ）

ISSN： 2709-6092

年卷期： 2024 年 14 卷 4 期

页码：

收录情况： SCI

摘要： The presence of trace antibiotics in water can lead to the development of drug-resistant bacterial strains, posing risks to ecosystems and human health. Immunomagnetic separation (IMS) using magnetic nanoparticles (MNPs) is an effective technique for targeted enrichment. This study established and optimized a separation system for the immunomagnetic microsphere enrichment of enrofloxacin (ENR) antibiotics, achieving efficient enrichment and isolation of ENR. To address potential elution degradation, an analysis of ENR degradation pathways and toxicity assessment of degradation products was performed. The study manifested the successful conjugation of antibodies to magnetic microspheres, leading to a 97.68% separation efficiency for ENR in water through IMS. Specifically, 1 mg of MNP@Ab could specifically bind to 1.5 ng of ENR at 37 degrees C for 30 min, and the elution rate exceeded 83%. No degradation products of ENR were detected during the enrichment and isolation procedures. Nevertheless, extending the elution time to 1 h disclosed three major degradation pathways with higher toxicity risks than ENR based on ecological risk assessment. To strictly control the elution temperature and elution time, the increase in temperature and time will heighten the risk of degradation products. This study presents an efficient strategy for water treatment and environmental protection.

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