文献类型： 外文期刊

作者： Bi, Shao-Shuai ¹ ; Jin, Hai-Tao ² ; Talukder, Milton ¹ ; Ge, Jing ¹ ; Zhang, Cong ¹ ; Lv, Mei-Wei ¹ ; Ismail, Mamoon A ¹ ;

作者机构： 1.Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China

2.Heilongjiang Acad Agr Sci, Qual & Safety Inst Agr Prod, Harbin 150010, Peoples R China

3.Patuakhali Sci & Technol Univ, Fac Anim Sci & Vet Med, Dept Physiol & Pharmacol, Barishal 8210, Bangladesh

4.Northeast Agr Univ, Coll Econ & Management, Harbin 150030, Peoples R China

5.Northeast Agr Univ, Key Lab Prov Educ, Dept Heilongjiang Common Anim Dis Prevent & Treat, Harbin 150030, Peoples R China

6.Northeast Agr Univ, Heilongjiang Key Lab Lab Anim & Comparat Med, Harbin 150030, Peoples R China

关键词： Nano-selenium; Cadmium; Heat shock response; Heat shock transcription factors; Heat shock protein pathway

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.025； 五年影响因子：5.847 ）

ISSN： 0278-6915

年卷期： 2021 年 154 卷

页码：

收录情况： SCI

摘要： Cadmium (Cd) is one of the toxic environmental heavy metals that poses health hazard to animals due to its toxicity. Nano-Selenium (Nano-Se) is a Nano-composite form of Se, which has emerged as a promising therapeutic agent for its protective roles against heavy metals-induced toxicity. Heat shock proteins (HSPs) play a critical role in cellular homeostasis. However, the potential protective effects of Nano-Se against Cd-induced cerebellar toxicity remain to be illustrated. To investigate the toxic effects of Cd on chicken's cerebellum, and the protective effects of Nano-Se against Cd-induced cerebellar toxicity, a total of 80 male chicks were divided into four groups and treated as follows: (A) 0 mg/kg Cd, (B) 1 mg/kg Nano-Se (C) 140 mg/kg Cd + 1 mg/kg Nano-Se (D) 140 mg/kg Cd for 90 days. We tested heat shock protein pathway-related factors including heat shock factors (HSFs) HSF1, HSF2, HSF3 and heat shock proteins (HSPs) HSP10, HSP25, HSP27, HSP40, HSP60, HSP70 and HSP90 expressions. Histopathological results showed that Cd treatment caused degradation of Purkinje cells. In addition, HSFs and HSPs expression decreased significantly in the Cd group. Nano-Se co-treatment with Cd enhanced the expression of HSFs and HSPs. In summary, our findings explicated a potential protective effect of Nano-Se against Cd-induced cerebellar injury in chicken, suggesting that Nano-Se is a promising therapeutic agent for the treatment of Cd toxicity.