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Immunomodulatory activities and subacute toxicity of a novel beta beta-glucan from Paenibacillus polymyxa JB115 in rats

文献类型： 外文期刊

作者： Chang, Zhi-Qiang 2 ; Reza, Md. Ahsanur 1 ; Lee, Joong-Su 1 ; Gebru, Elias 1 ; Jang, Seung-Hee 1 ; Choi, Myung-Jin 1 ;

作者机构： 1.Kyungpook Natl Univ, Coll Vet Med, Dept Pharmacol, Taegu 702701, South Korea

2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao, Peoples R China

3.Chonnam Natl Univ, Coll Vet Med, Anim Med Ctr, Kwangju, South Korea

关键词： beta-glucan;P. polymyxa JB115;Immunomodulatory;Subacute toxicity;rats

期刊名称：IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY （ 影响因子：2.73； 五年影响因子：2.917 ）

ISSN： 0892-3973

年卷期： 2011 年 33 卷 1 期

页码：

收录情况： SCI

摘要： Subacute toxicity and immunopharmacological activities of beta beta-glucan from P. polymyxa JB115 was evaluated in a 28-day feeding study in rats. The white blood cell count, red blood cell count, hematocrit, hemoglobin, thrombocytes (THR) and thrombocytocrit were significantly higher in male fed with beta beta-glucan than control rats and the insignificant lower eosinophil count, mean corpuscular volume, mean cell hemoglobin and uninfected THR (uTHR) levels were observed in male whereas no marked changes in female rats. No other significant differences in serum chemistry and liver, kidney, and spleen weights were observed. The pathological changes and other abnormal indicators were not detected in urine. Female rats fed with diet supplemented with 0.01% beta beta-glucan also showed marked increase in the percentage of blood cytotoxic T-lymphocytes compared to that of the control group while not significant differences in the percentage of blood B-lymphocytes. No adverse effects on general condition and behavior, growth, feed and water consumption and feed conversion efficiency were found. The results suggest that consumption of the novel beta beta-1, 3/1, 6-glucan from P. polymyxa JB115 was not associated with any obvious toxic effects in rats, indicating its safety as a potential immunostimulant or as an adjuvant of some animal vaccines.

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