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In Vitro Antioxidant and Anti-Inflammatory Activities of Protocatechualdehyde Isolated from Phellinus gilvus

文献类型： 外文期刊

作者： Chang, Zhi-Qiang 1 ; Gebru, Elias 1 ; Lee, Sam-Pin 3 ; Rhee, Man-Hee 1 ; Kim, Jong-Choon 4 ; Cheng, Henrique 5 ; Park, 1 ;

作者机构： 1.Kyungpook Natl Univ, Coll Vet Med, Taegu 702701, South Korea

2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China

3.Keimyung Univ, Dept Food Sci & Technol, Taegu 704701, South Korea

4.Chonnam Natl Univ, Coll Vet Med, Kwangju 500757, South Korea

5.Louisiana State Univ, Sch Vet Med, Baton Rouge, LA 70803 USA

关键词： Phellinus gilvus;protocatechualdehyde;DPPH;NO;RAW264.7 cells

期刊名称：JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY （ 影响因子：2.0； 五年影响因子：1.653 ）

ISSN： 0301-4800

年卷期： 2011 年 57 卷 1 期

页码：

收录情况： SCI

摘要： Although various biological activities of Phellinus gilvus (PG) have been reported, the active compounds responsible for these effects are not known. Here, we evaluated the activity of various solvent extracts of PG, and found the ethyl acetate extract (Fd) to be the most active fraction, showing a strong DPPH free radical scavenging activity, and inhibitory effects on LPS-induced nitric oxide (NO) production and COX-2 mRNA expression in RAW264.7 macrophages. Six major compounds were identified from the ethyl acetate extract of PG, and protocatechualdehyde (PCA) was supposed to be the major phenolic compound of PG responsible for its DPPH free radical scavenging activity and its inhibitory effects on LPS-induced NO production in RAW264.7 cells. Further in vitro and in vivo experiments are currently underway to confirm this observation and to investigate the detailed molecular mechanisms involved in the process as well as the biological activities of other fractions of Fd.

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