Two interacting transcriptional coactivators cooperatively control plant immune responses
文献类型： 外文期刊
作者： Chen, Huan 1 ; Li, Min 2 ; Qi, Guang 2 ; Zhao, Ming 2 ; Liu, Longyu 2 ; Zhang, Jingyi 1 ; Chen, Gongyou 5 ; Wang, Daowen; 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Plant Protect, Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base,Minist Sci & Technol, Nanjing 210014, Peoples R China
2.Univ South Carolina, Dept Biol Sci, Columbia, SC 29208 USA
3.Henan Agr Univ, State Key Lab Wheat & Maize Crop Sci, Zhengzhou 450002, Peoples R China
4.Henan Agr Univ, Coll Agron, Zhengzhou 450002, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Agr & Biol, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China
期刊名称：SCIENCE ADVANCES （ 影响因子：14.143； 五年影响因子：16.45 ）
ISSN： 2375-2548
年卷期： 2021 年 7 卷 45 期
页码：
收录情况： SCI
摘要： The phytohormone salicylic acid (SA) plays a pivotal role in plant defense against biotrophic and hemibiotrophic pathogens. NPR1 and EDS1 function as two central hubs in plant local and systemic immunity. However, it is unclear how NPR1 orchestrates gene regulation and whether EDS1 directly participates in transcriptional reprogramming. Here, we show that NPR1 and EDS1 synergistically activate pathogenesis-related (PR) genes and plant defenses by forming a protein complex and recruiting Mediator. We discover that EDS1 functions as an autonomous transcriptional coactivator with intrinsic transactivation domains and physically interacts with the CDK8 subunit of Mediator. Upon SA induction, EDS1 is directly recruited by NPR1 onto the PR1 promoter via physical NPR1-EDS1 interactions, thereby potentiating PR1 activation. We further demonstrate that EDS1 stabilizes NPR1 protein and NPR1 transcriptionally up-regulates EDS1. Our results reveal an elegant interplay of key coactivators with Mediator and elucidate important molecular mechanisms for activating transcription during immune responses.
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