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Antibacterial activities of coumarin-3-carboxylic acid against Acidovorax citrulli

文献类型： 外文期刊

作者： Zhu, Fa-Di 1 ; Fu, Xin 1 ; Ye, Huo-Chun 1 ; Ding, Hai-Xin 4 ; Gu, Liu-Shuang 1 ; Zhang, Jing 1 ; Guo, Yong-Xia 2 ; Feng, Gang 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Haikou, Peoples R China

2.Heilongjiang Bayi Agr Univ, Coll Agron, Daqing, Peoples R China

3.Minist Agr, Key Lab Monitoring & Control Trop Agr & Forest Inv, Haikou, Peoples R China

4.Jiangxi Sci & Technol Normal Univ, Inst Organ Chem, Key Lab Organ Chem, Nanchang, Peoples R China

5.Minist Agr & Rural Affairs, Key Lab Low Carbon Green Agr Northeastern China, Daqing, Peoples R China

关键词： coumarin-3-carboxylic acid; bactericidal activity; mechanism; biofilm; Acidovorax citrulli

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）

ISSN：

年卷期： 2023 年 14 卷

页码：

收录情况： SCI

摘要： Coumarin-3-carboxylic acid (3-CCA), previously screened from natural coumarins, was found to possess strong antibacterial activity against Acidovorax citrulli (Ac). In order to further evaluate the activity of this compound against plant bacterial pathogens and explore its potential value as a bactericidal lead compound, the activity of 3-CCA against 14 plant pathogenic bacteria in vitro and in vivo was tested. Results showed that 3-CCA exhibited strong in vitro activities against Ac, Ralstonia solanacearum, Xanthomonas axonopodis pv. manihotis, X. oryzae pv. oryzae, and Dickeya zeae with EC50 values ranging from 26.64 mu g/mL to 40.73 mu g/mL. Pot experiment results showed that 3-CCA had powerful protective and curative effects against Ac. In addition, the protective efficiency of 3-CCA was almost equivalent to that of thiodiazole copper at the same concentration. The results of SEM and TEM observation and conductivity tests showed that 3-CCA disrupted the integrity of the cell membrane and inhibited polar flagella growth. Furthermore, 3-CCA resulted in reductions in motility and extracellular exopolysaccharide (EPS) production of Ac while inhibiting the biofilm formation of Ac. These findings indicate that 3-CCA could be a promising natural lead compound against plant bacterial pathogens to explore novel antibacterial agents.

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