文献类型： 外文期刊
作者： Sun, Ruiyue 1 ; Li, Da 2 ; Sun, Mubai 2 ; Miao, Xinyu 2 ; Jin, Xin 3 ; Xu, Xifei 1 ; Su, Ying 2 ; Xu, Hongyan 1 ; Wang, Jinghui 2 ; Niu, Honghong 2 ;
作者机构： 1.Yanbian Univ, Coll Agr, Dept Food Sci & Engn, Yanji 133000, Jilin, Peoples R China
2.Jilin Acad Agr Sci, Inst Agroprod Proc, Changchun 130033, Jilin, Peoples R China
3.Jilin Agr Univ, Coll Food Sci & Engn, Changchun 130033, Jilin, Peoples R China
关键词： Bacillus natto; Obesity; Insulin resistance; PI3K; AKT
期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.322； 五年影响因子：3.498 ）
ISSN： 0006-291X
年卷期： 2022 年 603 卷
页码：
收录情况： SCI
摘要： Obesity has become the second leading cause of death globally after smoking. Probiotic Bacillus has noticeable weight-loss effects. This study aimed to investigate the mechanism of Bacillus natto (B. natto) on insulin resistance in obese rats. The obese rat model was established with a HFD for 8 weeks, and then, B. natto was orally administered at different dosed for 8 weeks. The results showed that B. natto significantly reduced the body weight, epididymis fat weight, total cholesterol, triglyceride, low-density lipoprotein while increasing the level of high-density lipoprotein in HFD rats. B. natto intervention improved liver injury by reducing alanine aminotransferase and aspartate transaminase levels. B. natto intervention was also beneficial for the inhibition of hepatic steatosis and inflammation factors in HFD rats by inhibiting the mRNA expression level of SREBP-1 gene. Moreover, B. natto improved insulin resistance homeostasis by activating PI3K/AKT signaling pathway. Therefore, B. natto could be used as a potential probiotic supplement to provided new strategy for the prevention and treatment of metabolic diseases such as obesity. (c) 2022 Elsevier Inc. All rights reserved.
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