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Polysaccharide from Artocarpus heterophyllus Lam. (Jackfruit) Pulp Ameliorates Dextran Sodium Sulfate-Induced Enteritis in Rats

文献类型： 外文期刊

作者： Li, Yunlong 1 ; Chen, Yuzi 2 ; Li, Chuan 1 ; Wu, Gang 2 ; He, Yanfu 1 ; Tan, Lehe 2 ; Zhu, Kexue 2 ;

作者机构： 1.Hainan Univ, Sch Food Sci & Engn, Haikou 570228, Peoples R China

2.Spice & Beverage Res Inst, Chinese Acad Trop Agr Sci, Wanning 571533, Peoples R China

3.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China

4.Key Lab Proc Suitabil & Qual Control Special Trop, Wanning 571533, Peoples R China

5.Natl Ctr Important Trop Crops Engn & Technol Res, Wanning 571533, Peoples R China

关键词： Artocarpus heterophyllus Lam.; polysaccharide; signaling pathway; inflammation; intestinal barrier

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.6； 五年影响因子：6.2 ）

ISSN： 1661-6596

年卷期： 2024 年 25 卷 3 期

页码：

收录情况： SCI

摘要： A polysaccharide from Artocarpus heterophyllus Lam. (jackfruit) pulp (JFP-Ps) is known for its excellent bioactivities. However, its impact on small intestinal barrier function is still largely unexplored. The study aimed to examine the protection effect of JFP-Ps against dextran sodium sulfate-induced enteritis and its underlying mechanism. This research revealed that JFP-Ps mitigated small intestinal tissue damage by reducing the expression of pro-inflammatory cytokines and promoting the expression of the anti-inflammatory cytokine interleukin-10 in the small intestine. JFP-Ps diminished oxidative stress by bolstering the activity of antioxidant enzymes and reducing the concentration of malondialdehyde in the small intestine. In addition, JFP-Ps may restore the mechanical barrier and inhibit intestinal structure damage by augmenting the expression of short-chain fatty acids (SCFAs) receptors (GPR41/43) and up-regulating the expression of tight junction proteins (occludin). In conclusion, JFP-Ps may positively influence intestinal health by relieving oxidative stress in the small intestine, improving mechanical barrier function, activating the SCFA-GPR41/GPR43 axis, and inhibiting TLR4/MAPK pathway activation. The results augment our comprehension of the bioactivities of JFP-Ps, corroborating its great potential as a functional food.

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