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Artemisinin alters disposition regularities of enrofloxacin and its metabolite ciprofloxacin in channel catfish (Ictalurus punetaus) following combined oral administration

文献类型： 外文期刊

作者： Liu, Yongtao 1 ; Zhang, Guodong 1 ; Yang, Yibin 1 ; Zhou, Shun 1 ; Dong, Jing 1 ; Yang, Qiuhong 1 ; Xu, Ning 1 ; Ai, Xiaohui 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan, Peoples R China

2.Minist Agr & Rural Affairs, Key Lab Aquat Prod Qual & Safety Control, Beijing, Peoples R China

3.Hubei Prov Engn & Technol Res Ctr Aquat Prod Qual, Wuhan, Peoples R China

4.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China

关键词： Artemisinin; Enrofloxacin; Channel catfish; Pharmacokinetics; Multi-drug resistance 1

期刊名称：AQUACULTURE （ 影响因子：4.5； 五年影响因子：4.6 ）

ISSN： 0044-8486

年卷期： 2023 年 572 卷

页码：

收录情况： SCI

摘要： The aim of this investigation was to explore the effect of artemisinin (ART) on pharmacokinetic (PK) and tissue distribution characteristics of enrofloxacin (ENR) and ciprofloxacin (CIP) in channel catfish following combined and single medicine. The channel catfish in ENR group were treated with ENR, and the fish in ENR-ART group were orally co-administrated with ENR and ART. ENR and CIP concentrations in channel catfish were determined using ultra performance liquid chromatography, and PK parameters for ENR and CIP were calculated by Win-Nonlin software. Moreover, the multi-drug resistance 1 (MDR1) gene expression and cytochrome P-450 3A (CYP 3A) enzyme activities in channel catfish liver were measured. The results showed that lower ENR and CIP levels were observed in ENR-ART group than that in ENR group, and similar regularities in PK parameters were also found that Cmax, AUC and MRT values in ENR group were all greater than those in ENR-ART group. Furthermore, higher MDR1 gene expression and CYP 3A enzyme activities in channel catfish liver were observed in ENR-ART group than those in ENR group. The present investigation indicates that ART can reduce the ENR concentrations, accelerate the excretion of ENR and decrease the antibacterial efficacy of ENR in channel catfish.

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