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Effect of environmental level of methomyl on hatching, morphology, immunity and development related genes expression in zebrafish (Danio rerio) embryo

文献类型： 外文期刊

作者： Meng, Shun Long 1 ; Li, Ming Xiao 1 ; Lu, Yan 1 ; Chen, Xi 1 ; Wang, Wei Ping 4 ; Song, Chao 1 ; Qiu, Li Ping 2 ; Li, Dan Dan 2 ; Xu, Hui Min 2 ; Xu, Pao 1 ;

作者机构： 1.Nanjing Agr Univ, Wuxi Fishery Coll, Wuxi 214081, Peoples R China

2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 214081, Peoples R China

3.Sci Observing & Expt Stn Fishery Resources & Envir, Wuxi 214081, Peoples R China

4.Jiangxi Prov Aquat Biol Protect & Rescue Ctr, Nanchang 330029, Peoples R China

关键词： Methomyl; Ecotoxicology; Zebrafish embryo; Embryo morphology; Develop associated genes

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.8； 五年影响因子：6.9 ）

ISSN： 0147-6513

年卷期： 2023 年 268 卷

页码：

收录情况： SCI

摘要： The extensive use of carbamate pesticides has led to a range of environmental and health problems, such as surface and groundwater contamination, and endocrine disorders in organisms. In this study, we focused on examining the effects of toxic exposure to the carbamate pesticide methomyl on the hatching, morphology, immunity and developmental gene expression levels in zebrafish embryos. Four concentrations of methomyl (0, 2, 20, and 200 mu g/L) were administered to zebrafish embryos for a period of 96 h. The study found that exposure to methomyl accelerated the hatching process of zebrafish embryos, with the strongest effect recorded at the concentration of 2 mu g/L. Methomyl exposure also trigged significantly reductions in heart rate and caused abnormalities in larvae morphology, and it also stimulated the synthesis and release of several inflammatory factors such as IL-1 beta, IL-6, TNF-alpha and INF-alpha, lowered the IgM contents, ultimately enhancing inflammatory response and interfering with immune function. All of these showed the significant effects on exposure time, concentration and their interaction (Time x Concentration). Furthermore, the body length of zebrafish exposed to methomyl for 96 h was significantly shorter, particularly at higher concentrations (200 mu g/L). Methomyl also affected the expression levels of genes associated with development (down-regulated igf1, bmp2b, vasa, dazl and piwi genes), demonstrating strong developmental toxicity and disruption of the endocrine system, with the most observed at the concentration of 200 mu g/L and 96 h exposure to methomyl. The results of this study provide valuable reference information on the potential damage of methomyl concentrations in the environment on fish embryo development, while also supplementing present research on the immunotoxicity of methomyl.

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