DEAD/DEAH-box helicase 5 is hijacked by an avian oncogenic herpesvirus to inhibit interferon beta production and promote viral replication
文献类型： 外文期刊
作者： Xu, Jian 1 ; Cai, Yunhong 1 ; Ma, Zhenbang 2 ; Jiang, Bo 1 ; Liu, Wenxiao 1 ; Cheng, Jing 1 ; Jin, Huan 1 ; Li, Yongqing 1 ;
作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100097, Peoples R China
2.Jiangxi Agr Univ, Coll Anim Sci & Technol, Nanchang 330045, Jiangxi, Peoples R China
关键词： Avian oncogenic herpesvirus; DEAD-box helicase 5; Interferon beta; Interferon regulatory factor 1; MDA5/TLR3 signaling
期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：3.636； 五年影响因子：3.654 ）
ISSN： 0145-305X
年卷期： 2021 年 119 卷
页码：
收录情况： SCI
摘要： DEAD-box helicase 5 (DDX5) plays a significant role in tumorigenesis and regulates viral replication of several viruses. An avian oncogenic herpesvirus, Marek's disease virus (MDV), is widely known to cause immunosuppression and lymphoma in chickens. However, the underlying mechanisms of how DDX5 plays a role in viral replication remain unclear. In this study, we show that MDV inhibits the production of interferon beta (IFN-beta) in chicken embryo fibroblasts (CEFs) by increasing the expression level and promoting the nuclear aggregation of DDX5. We further reveal how DDX5 down-regulates melanoma differentiation-associated gene 5/toll-like receptor 3 signaling through the fundamental transcription factor, interferon regulatory factor 1. MDV replication is suppressed, and the production of IFN-beta is promoted in the DDX5 absented CEFs. Taken together, our investigations demonstrate that MDV inhibits IFN-beta production by targeting DDX5-mediated signaling to facilitate viral replication, which offers a novel insight into the mechanism by which an avian oncogenic herpesvirus replicates in chicken cells.
- 相关文献
作者其他论文 更多>>
-
Highly pathogenic bovine viral diarrhea virus BJ-11 unveils genetic evolution related to virulence in calves
作者：Zhang, Yuanyuan;Cheng, Jing;Guo, Yu;Hu, Yibin;Liu, Wenxiao;Zhou, Linyi;Cheng, Chunjie;Yang, Chun;Yang, Jing;Li, Yongqing;Zhang, Yuanyuan;Du, Enqi;Guo, Yu;Hu, Yibin;Zhao, Zhuo;Wu, Peize;Cheng, Chunjie;Yang, Chun;Yang, Jing;Li, Yongqing
关键词：bovine viral diarrhea virus; lethal strain; BVDV 1b; glycoprotein mutations; evolve; vaccination strategies
-
Marek's disease virus-encoded microRNA-M6-5p facilitates viral latent infection by targeting histone demethylase KDM2B
作者：Zhou, Linyi;Zhu, Runan;Jiang, Bo;Cheng, Jing;Liu, Wenxiao;Li, Yongqing;Zhou, Linyi;Jiang, Bo;Cheng, Jing;Liu, Wenxiao;Li, Yongqing;Zhou, Linyi;Jiang, Bo;Cheng, Jing;Liu, Wenxiao;Li, Yongqing;Zhu, Runan;Yao, Yongxiu;Yao, Yongxiu
关键词：MDV; latent infection; miRNAs; epigenetic regulation; KDM2B
-
Identification of three novel B cell epitopes targeting the bovine viral diarrhea virus NS3 protein for use in diagnostics and vaccine development
作者：Zhang, Yuanyuan;Du, Enqi;Zhang, Yuanyuan;Cheng, Jing;Liu, Wenxiao;Zhou, Linyi;Yang, Chun;Li, Yongqing;Zhang, Yuanyuan;Cheng, Jing;Liu, Wenxiao;Zhou, Linyi;Yang, Chun;Li, Yongqing;Zhang, Yuanyuan;Cheng, Jing;Liu, Wenxiao;Zhou, Linyi;Yang, Chun;Li, Yongqing;Du, Enqi;Yang, Chun;Li, Yongqing
关键词：Bovine viral diarrhea virus; NS3 protein; Monoclonal antibody; Epitope mapping; Alanine scanning; Replication inhibition; Diagnostic method
-
Marek's disease virus-encoded MicroRNA-M6-5p suppresses viral replication by targeting viral major capsid protein-coding gene UL19
作者：Zhou, Linyi;Yang, Jing;Cheng, Jing;Liu, Wenxiao;Wang, Yong;Li, Yongqing;Yang, Jing;Zhou, Linyi;Cheng, Jing;Liu, Wenxiao;Wang, Yong;Li, Yongqing;Zhou, Linyi;Cheng, Jing;Liu, Wenxiao;Wang, Yong;Li, Yongqing
关键词：Marek's disease virus; MiRNA; Replication; Viral capsid; UL19
-
Three-dimensional trajectory extraction and flower structure coupling method for bee-flower interactions
作者：Leng, Ying;Feng, Shuaiqi;Zhong, Ziyi;Xu, Jian;Wu, Sheng;Wen, Weiliang;Wu, Sheng;Guo, Minkun;Wen, Weiliang
关键词：Nectar guides; Three-dimensional; Trajectory; Floral structure; mu-CT; Ultraviolet; RGB-D vision
-
Development and evaluation of a time-resolved fluorescence labelled immunochromatographic strip assay for rapid and quantitative detection of bovine herpesvirus 1
作者：Liu, Wenxiao;Zhang, Kun;Cheng, Jing;Cheng, Chunjie;Jiang, Bo;Zhou, Linyi;Li, Yongqing;Liu, Wenxiao;Cheng, Jing;Jiang, Bo;Zhou, Linyi;Li, Yongqing;Zhang, Kun;Yu, Shiqiang
关键词：bovine herpesvirus 1; diagnosis; lateral flow strip; time-resolved fluorescent microspheres; monoclonal antibody
-
Identification and structural analysis of dimeric chicken complement component 3d and its binding with chicken complement receptor 2
作者：Jin, Huan;Tu, Min;Jiang, Bo;Li, Yongqing;Zhang, Zhenhua;Meng, Zhaoying;Yang, Qianqian;Jiang, Bo;Li, Yongqing
关键词：Chicken complement component 3d; Dimer; Homologous modeling; Chicken complement receptor 2; Surface plasmon resonance; Molecular docking
