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Immunopathological comparison of in ovo and post-hatch vaccination techniques for infectious bursal disease vaccine in layer chicks

文献类型： 外文期刊

作者： Zaheer, Iqra 1 ; Chen, Wei 2 ; Khan, Ahrar 3 ; Elokil, Abdelmotaleb 4 ; Saleemi, Muhammad Kashif 1 ; Zaheer, Tean 5 ; Khan, Muhammad Zargham 1 ;

作者机构： 1.Univ Agr Faisalabad, Dept Pathol, Faisalabad, Pakistan

2.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Livestock & Poultry Breeding, Key Lab Guangdong Publ Lab Anim Breeding & Nutr,An, Guangzhou, Peoples R China

3.Shandong Vocat Anim Sci & Vet Coll, Dept Anim Sci & Technol, Weifang, Peoples R China

4.Benha Univ, Fac Agr, Dept Anim Prod, Banha, Egypt

5.Univ Agr Faisalabad, Dept Parasitol, Faisalabad, Pakistan

关键词： IBD; in-ovo; vaccine; immunopathology; layers

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.471； 五年影响因子：3.821 ）

ISSN：

年卷期： 2022 年 9 卷

页码：

收录情况： SCI

摘要： This study was designed to compare immunopathological effects of in ovo vaccination with post-hatch vaccination against IBD in White Leghorn chicks. A total of 189 embryonated eggs were divided into six groups. At day 18 of incubation, groups A-C were administered in ovo with 228E, Winterfield 2512:10/3 and 2512/90:10/2.7, respectively, group D (post-hatch vaccination) and group E as shamed control (for quality evaluation of in ovo vaccination technique), and group F as control. The results showed that antibody titers against IBD detected by ELISA on days 2, 17, and 28 were significantly higher in all in ovo groups as compared to control groups E and F. On day 17, all vaccinated groups (in ovo and post-hatch vaccinated) showed no significant differences in antibody titers among themselves; however, at day 28, only the post-hatch group showed significantly higher antibody titers followed by in ovo vaccinated groups. The cell-mediated immunity determined by PHA-P assay was significantly higher in all vaccinated groups than the non-vaccinated groups. No clinical signs of IBD infection were observed in any of the vaccinated groups. There was only increase in bursa size of groups vaccinated with intermediate plus strains (groups A, C, and D) at day 28. The histopathology showed that all the treatment groups had mild lesions induced by IBD virus in bursa. This study concluded that in ovo vaccination with live IBD vaccines provides protective immunity to the chickens even in the presence of IBD-specific MDA; therefore, the onset of immunity was much earlier than the post-hatch vaccination and in ovo groups also maintained protective immunity against IBD for longer time.

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