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H2AK121ub in Arabidopsis associates with a less accessible chromatin state at transcriptional regulation hotspots

文献类型： 外文期刊

作者： Yin, Xiaochang 1 ; Romero-Campero, Francisco J. 2 ; de los Reyes, Pedro 2 ; Yan, Peng 4 ; Yang, Jing 5 ; Tian, Guan 1 ;

作者机构： 1.Peking Univ, Peking Tsinghua Ctr Life Sci, Sch Adv Agr Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China

2.CSIC, IBVF, Inst Plant Biochem & Photosynth, Ave Americo Vespucio 49, Seville 41092, Spain

3.Univ Seville, Dept Comp Sci & Artificial Intelligence, Ave Reina Mercedes S-N, Seville 41012, Spain

4.Zhejiang Univ, Coll Life Sci, State Key Lab Plant Physiol & Biochem, Hangzhou 310058, Peoples R China

5.Beijing Acad Agr & Forestry Sci, Beijing Agrobiotechnol Res Ctr, Beijing Key Lab Agr Genet Resources & Biotechnol, Beijing 100097, Peoples R China

6.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China

7.Shandong Normal Univ, Life Sci Coll, Key Lab Plant Stress, Jinan 250014, Peoples R China

期刊名称：NATURE COMMUNICATIONS （ 影响因子：14.919； 五年影响因子：15.805 ）

ISSN： 2041-1723

年卷期： 2021 年 12 卷 1 期

页码：

收录情况： SCI

摘要： Although it is well established that the Polycomb Group (PcG) complexes maintain gene repression through the incorporation of H2AK121ub and H3K27me3, little is known about the effect of these modifications on chromatin accessibility, which is fundamental to understand PcG function. Here, by integrating chromatin accessibility, histone marks and expression analyses in different Arabidopsis PcG mutants, we show that PcG function regulates chromatin accessibility. We find that H2AK121ub is associated with a less accessible but still permissive chromatin at transcriptional regulation hotspots. Accessibility is further reduced by EMF1 acting in collaboration with PRC2 activity. Consequently, H2AK121ub/H3K27me3 marks are linked to inaccessible although responsive chromatin. In contrast, only-H3K27me3-marked chromatin is less responsive, indicating that H2AK121ub-marked hotspots are required for transcriptional responses. Nevertheless, despite the loss of PcG activities leads to increased chromatin accessibility, this is not necessarily accompanied by transcriptional activation, indicating that accessible chromatin is not always predictive of gene expression.

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