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Isolation, identification, and pathogenicity of a goose astrovirus causing fatal gout in goslings

文献类型： 外文期刊

作者： Zhu, Qinghe 1 ; Miao, Yan 2 ; Wang, Jun 1 ; Bai, Wenfei 1 ; Yang, Xu 1 ; Yu, Shiping 1 ; Guo, Donghua 1 ; Sun, Dongbo 1 ;

作者机构： 1.Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, 5 Xinfeng Rd, Daqing 163319, Peoples R China

2.Heilongjiang Acad Agr Sci, Branch Anim Husb & Vet, Qiqihar 161000, Peoples R China

关键词： Goose astrovirus; Identification; Whole-genome sequence; Pathogenicity; Goose gout

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.246； 五年影响因子：3.565 ）

ISSN： 0378-1135

年卷期： 2022 年 274 卷

页码：

收录情况： SCI

摘要： Since November 2016, severe infectious diseases characterized by gout and kidney swelling and caused by goose astrovirus (GoAstV) have affected goslings in major goose-producing areas in China. In 2021, a similar serious infectious disease broke out in commercial goose farms in Heilongjiang Province, China. In this study, strain HLJ2021 was successfully isolated from goose embryos. Electron microscopy showed that the viral particles are spherical, with a diameter of about 28 nm. The complete genomic length of strain HLJ2021 is 7210 nt, and it encodes three viral proteins. A phylogenetic analysis showed that strain HLJ2021 belongs to GoAstV-2 (G2). Compared with the two original GoAstV strains, amino acid site 540Q of the strain HLJ2021 spike domain has a mutation that affects the protein structure. One potential recombination event occurred between strains HLJ2021 and AstV/HB01/Goose/0123/19, which led to the generation of recombinant strain AstV/HN03/ Goose/0402/19. Strain HLJ2021 also showed strong pathogenicity in goslings. Goslings infected with GoAstV began to die at 48 h post-infection (hpi), with a mortality rate of 83.3% at 240 hpi. At autopsy, visceral urate deposits, severe renal hemorrhage and swelling, and urate in the ureter were observed in the dead goslings. These findings extend our understanding of the evolution of GoAstV, which causes gout. The isolated GoAstV strain HLJ2021 provides a potential resource for the development of biological products for the prevention of goose gout.

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