文献类型： 外文期刊
作者： Zhai, Yaying 1 ; Shi, Qiaoting 1 ; Chu, Qiuxia 1 ; Chen, Fuying 1 ; Feng, Yajie 1 ; Zhang, Zijing 1 ; Qi, Xinglei 3 ; Arends, Danny 4 ; Brockmann, Gudrun A. 5 ; Wang, Eryao 1 ; Lyu, Shijie 1 ;
作者机构： 1.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou, Henan, Peoples R China
2.Henan Agr Univ, Coll Anim Sci & Vet Med, Zhengzhou, Peoples R China
3.Ctr Anim Husb Tech Serv Biyang, Zhumadian, Peoples R China
4.Northumbria Univ, Dept Appl Sci, Newcastle Upon Tyne, England
5.Humboldt Univ, Albrecht Daniel Thaer Inst Agr & Hort Sci, Berlin, Germany
6.Shennong Lab, Zhengzhou, Henan, Peoples R China
关键词： bovine; uterine flushing; receptive endometrium; apoptosis; proliferation
期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.471； 五年影响因子：3.821 ）
ISSN：
年卷期： 2022 年 9 卷
页码：
收录情况： SCI
摘要： Intrauterine exosomes have been identified to be involved in the embryo development and implantation. The aim of this study was to explore the role of miRNAs in intrauterine exosomes in bovine pregnancy. Intrauterine exosomes were collected from uterine flushing fluids of three donor and three recipient Xianan cows 7 days after fertilization. Intrauterine exosomes miRNAs were extracted and the exosomal miRNAs expression levels were analyzed. Sixty miRNAs differed significantly in their amounts between donors and recipients (p-value < 0.05, |log2(FoldChange)| > 1). Twenty-two miRNAs were upregulated and 38 downregulated in the group of donor cows. The bta-miR-184 was the most significant (PBenjamini-Hochberg < 0.001). A total of 9,775 target genes were predicted using the 60 miRNAs. GO and KEGG analysis showed that the target genes were enriched in several biological processes or pathways associated with embryo implantation and endometrial development, such as cell adhesion, cell junction, focal adhesion, and Rap1 signaling pathway. Our findings suggest that, in cattle early pregnancy stage, these differently expressed miRNAs in intrauterine exosomes involved in embryo implantation and endometrial development, which may exert a significant effect and influence the uterine microenvironment for embryo implantation. These results could provide reference for screening and exploring the intrauterine exosomal miRNA affecting embryo implantation.
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