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Physiological and Neurobehavioral Disturbances Induced by Al2O3 Nanoparticle Intoxication in Nile Tilapia Fish: Benefits of Dietary Chamomile Essential Oil

文献类型： 外文期刊

作者： Farag, Mayada R. 1 ; Zheng, Chuntian 2 ; Gharib, Heba S. A. 3 ; EL-Hady, Enas 4 ; Mahdy, Eman A. A. 4 ; Abo-Elmaaty, Azza M. A. 5 ; Abou-Zeid, Shimaa M. 6 ; Alagawany, Mahmoud 7 ; Di Cerbo, Alessandro 8 ; Azzam, Mahmoud M. 9 ; Al-Abdullatif, Abdulaziz A. 9 ; Hassan, Mona A. 1 ;

作者机构： 1.Zagazig Univ, Vet Med Fac, Forens Med & Toxicol Dept, Zagazig 44519, Egypt

2.Guangdong Acad Agr Sci, State Key Lab Livestock & Poultry Breeding, Key Lab Anim Nutr & Feed Sci South China, Inst Anim Sci,Minist Agr,Guangdong Publ Lab Anim B, Guangzhou 510640, Peoples R China

3.Zagazig Univ, Fac Vet Med, Behav & Management Anim Poultry & Aquat Dept, Zagazig 44511, Egypt

4.Zagazig Univ, Anat & Embryol Dept, Vet Med Fac, Zagazig 44519, Egypt

5.Zagazig Univ, Fac Vet Med, Pharmacol Dept, Zagazig 44519, Egypt

6.Univ Sadat City, Fac Vet Med, Dept Forens Med & Toxicol, Sadat City 6012201, Egypt

7.Zagazig Univ, Fac Agr, Poultry Dept, Zagazig 44519, Egypt

8.Univ Camerino, Sch Biosci & Vet Med, Matelica, Italy

9.King Saud Univ, Coll Food & Agr Sci, Dept Anim Prod, Riyadh 11451, Saudi Arabia

期刊名称：AQUACULTURE NUTRITION （ 影响因子：3.5； 五年影响因子：3.6 ）

ISSN： 1353-5773

年卷期： 2023 年 2023 卷

页码：

收录情况： SCI

摘要： Despite the usage of nanoparticles (NPs) is rapidly increasing, several experts have noted the risk of their release into ecosystems and their potential negative impacts on biological systems. However, the available studies on the neurobehavioral impacts of aluminum oxide nanoparticles (Al(2)O(3)NPs) on aquatic organisms are little. Hence, this study targeted to ascertain the harmful effects of Al(2)O(3)NPs on behavioral characteristics and genotoxic and oxidative damages in Nile tilapia fish. In addition, the beneficial role of chamomile essential oil (CEO) supplementation in reducing these effects was also investigated. In the current study, fish were distributed into 4 equal groups (n=60 fish per group). The control group was fed a plain diet only, the CEO group received a basic diet complemented with CEO at a level of 2 mg/kg diet, the ALNP group received a basic diet and was exposed to an approximate concentration of 1/10th LC50 of ALNPs nearly 5.08 mg/L, and the combination group (ALNPs/CEO group) received a basal diet coadministered with ALNPs and CEO at the aforementioned percentages. The findings revealed that O. niloticus exhibit neurobehavioral changes along with changes in the level of GABA, monoamines in the brain tissue, and serum amino acid neurotransmitters, besides a reduction of AChE and Na+/K+-ATPase activities. In addition to brain tissue oxidative damage with upregulation of proinflammatory and stress genes, such as HSP70 and caspase-3, supplementation of CEO significantly reduced the negative impacts of ALNPs. These results showed that CEO has neuroprotective, antioxidant, genoprotective, anti-inflammatory, and antiapoptotic properties in fish that have been exposed to ALNPs. Therefore, we advise its usage as a valuable addition to fish diet.

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