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Synthesis of fluorescent artificial receptors with high specificity for simultaneous detection of non-steroidal anti-inflammatory drugs

文献类型: 外文期刊

作者: Wang, Tingting 1 ; Li, Qianjin 1 ; Wang, Meng 1 ; Xu, Jianhong 3 ; Li, Jianlin 1 ; Wang, Fenying 2 ;

作者机构: 1.Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210023, Peoples R China

2.Nanchang Univ, Coll Chem, Nanchang 330031, Peoples R China

3.Jiangsu Acad Agr Sci, Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base, Minist Sci & Technol, Nanjing 210014, Peoples R China

关键词: Molecularly imprinted polymer; Fluorescence; Naproxen; Ketoprofen; Sensor

期刊名称:FOOD CHEMISTRY ( 影响因子:8.8; 五年影响因子:8.6 )

ISSN: 0308-8146

年卷期: 2023 年 410 卷

页码:

收录情况: SCI

摘要: Development of multiple detection methods to monitor non-steroidal anti-inflammatory drugs (NSAIDs) in food is an effective way to protect human health. Here, we aimed to synthesize fluorescent artificial receptors by molecular imprinting technique to construct a simultaneous detection system targeting NSAIDs. Rhodamine B and fluorescein-functionalized silanes were employed as the fluorescence signal reporters for naproxen and ketoprofen, respectively. Two fluorescent molecularly imprinted polymers (FMIPs) were obtained with high specificity, giving cross-reactivity factors of 6.4-15.8 (naproxen) and 2.6-25.6 (ketoprofen). Both FMIPs also displayed rapid response time (5 min) and high sensitivity (detection limit at similar to nM level). A simultaneous detection system was constructed based on the FMIPs and applied for sensing the spiked NSAIDs in real samples, showing recoveries of 71-119 %, comparable with the HPLC methods (70-113 %). In summary, use of different FMIPs to construct simultaneous detection systems is practicable, and provides a flexible way for sensing multiple hazards in food samples.

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