您好，欢迎访问上海市农业科学院 机构知识库！
上海市农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Magnolol, a Neolignan-like Drug, Inhibits Porcine Epidemic Diarrhea Virus Replication in Cultured Cells

文献类型： 外文期刊

作者： Wang, Xiaoting 1 ; Chen, Bingqing 2 ; Yu, Ruisong 2 ; Si, Fusheng 2 ; Xie, Chunfang 2 ; Li, Zhen 2 ; Dong, Shijuan 2 ; Zhang, Daojing 1 ;

作者机构： 1.East China Univ Sci & Technol ECUST, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

2.Shanghai Acad Agr Sci SAAS, Inst Anim Husb & Vet Sci, Shanghai Engn Res Ctr Breeding Pig, Shanghai Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China

关键词： porcine epidemic diarrhea virus (PEDV); magnolol; antiviral effect; in vitro

期刊名称：PATHOGENS （ 影响因子：3.7； 五年影响因子：3.7 ）

ISSN：

年卷期： 2023 年 12 卷 2 期

页码：

收录情况： SCI

摘要： Porcine epidemic diarrhea virus (PEDV) is a destructive pathogen that continues to adversely affect the swine industry worldwide due to a current lack of vaccines and drugs capable of effective disease control. In the present study, the neolignan-like drug, magnolol (MAG), was tested for its ability to inhibit a Vero-cell adapted PEDV strain DR13(att). Our data revealed that MAG exhibited anti-PEDV activity in vitro, with IC50 and CC50 values of 28.21 mu M and 57.28 mu M, respectively. MAG was an efficient inhibitor of viral replication, and repression of viral proliferation was strongest when the host cells were exposed to MAG and the virus at the same time. Although our data indicate that MAG has the potential to be a useful PEDV control agent, in vivo testing of the drug, using animal hosts, is required.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：上海市农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台