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Uncovering the biogeography of the microbial commmunity and its association with nutrient metabolism in the intestinal tract using a pig model

文献类型： 外文期刊

作者： Song, Yuanyuan 1 ; Chen, Kai 3 ; Lv, Lu 1 ; Xiang, Yun 4 ; Du, Xizhong 4 ; Zhang, Xiaojun 4 ; Zhao, Guangmin 1 ; Xiao, Yingping 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou, Peoples R China

2.Huzhou Univ, Sch Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang Pr, Huzhou, Peoples R China

3.Zhejiang Ctr Anim Dis Control, Qual & Safety Anim Prod Grp, Hangzhou, Peoples R China

4.Jinhua Acad Agr Sci, Inst Anim Husb & Vet Med, Jinhua, Peoples R China

关键词： gut microbiota; short-chain fatty acids; nutrients; amino acid; intestinal tract

期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.59； 五年影响因子：6.873 ）

ISSN： 2296-861X

年卷期： 2022 年 9 卷

页码：

收录情况： SCI

摘要： The gut microbiota is a complex ecosystem that is essential for the metabolism, immunity and health of the host. The gut microbiota also plays a critical role in nutrient absorption and metabolism, and nutrients can influence the growth and composition of the gut microbiota. To gain a better understanding of the relationship between the gut microbial composition and nutrient metabolism, we used a pig model by collecting the contents of the different intestinal locations from six pigs to investigate microbial composition in different intestinal locations based on 16S rRNA gene sequencing and the concentrations of short-chain fatty acids (SCFAs), amino acids, fat, and crude ash in different intestinal locations using gas chromatography and chemical analysis. The results showed that the richness and diversity of intestinal microbial communities gradually increased from the small intestine to the large intestine. The relative abundance of Proteobacteria was higher in the jejunum and ileum, whereas the proportion of Firmicutes was higher in the cecum and colon. The concentrations of SCFAs were higher in the cecum and colon (P < 0.05). The concentrations of amino acids were higher in the small intestine than in the large intestine, while the amino acid content was significantly higher in the ascending colon than in the transverse colon and descending colon. The correlation analysis revealed that Ruminococcaceae UCG-005, Coriobacteriaceae_uncultured, [Eubacterium] hallii group, Mogibacterium and Lachnospiraceae AC2044 group had a higher positive correlation with SCFAs, crude ash and fat but had a negative correlation with amino acids in different gut locations of pigs. These findings may serve as fundamental data for using nutrient metabolism to regulate human and animal gut microbes and health and provide guidance for exploring host-microbe bidirectional interaction mechanisms and driving pathways.

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