Phenylhydrazone Alkaloids from the Deep-Sea Cold Seep Derived Fungus Talaromyces amestolkiae HDN21-0307
文献类型： 外文期刊
作者： Wu, Jiajin 1 ; Wang, Wenxue 1 ; Yang, Yuhuan 1 ; Shah, Mudassir 1 ; Peng, Jixing 2 ; Zhou, Luning 1 ; Zhang, Guojian 1 ; Che, Qian 1 ; Li, Jing 1 ; Zhu, Tianjiao 1 ; Li, Dehai 1 ;
作者机构： 1.Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China
2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Testing & Evaluat Aquat Prod Safety & Qual, Minist Agr & Rural Affairs, Qingdao 266071, Peoples R China
3.Qingdao Marine Sci & Technol Ctr, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
4.Ocean Univ China, Sanya Oceanog Inst, Sanya 572025, Peoples R China
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：5.1； 五年影响因子：4.5 ）
ISSN： 0163-3864
年卷期： 2024 年 87 卷 5 期
页码：
收录情况： SCI
摘要： Alkaloids with a phenylhydrazone architecture are rarely found in nature. Four unusual phenylhydrazone alkaloids named talarohydrazones A-D (1-4) were isolated from the deep-sea cold seep derived fungus Talaromyces amestolkiae HDN21-0307 using the one strain-many compounds (OSMAC) approach and MS/MS-based molecular networking (MN) combined with network annotation propagation (NAP) and the unsupervised substructure annotation method MS2LDA. Their structures were elucidated by spectroscopic data analysis, single-crystal X-ray diffraction, and quantum chemical calculations. Talarohydrazone A (1) possessed an unusual skeleton combining 2,4-pyridinedione and phenylhydrazone. Talarohydrazone B (2) represents the first natural phenylhydrazone-bearing azadophilone. Bioactivity evaluation revealed that compound 1 exhibited cytotoxic activity against NCI-H446 cells with an IC50 value of 4.1 mu M. In addition, compound 1 displayed weak antibacterial activity toward Staphylococcus aureus with an MIC value of 32 mu g/mL.
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