Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse
文献类型： 外文期刊
作者： Wu, Jianghong 1 ; Gong, Husile 1 ; Bai, Yongsheng 5 ; Zhang, Wenguang 1 ;
作者机构： 1.Inner Mongolia Agr Univ, Coll Anim Sci, Hohhot 010018, Peoples R China
2.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot 010031, Peoples R China
3.Chinese Acad Sci, Inner Mongolia Prataculture Res Ctr, Hohhot 010031, Peoples R China
4.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Peoples R China
5.Indiana State Univ, Dept Biol, Terre Haute, IN 47809 USA
6.Indiana State Univ, Ctr Genom Advocacy, Terre Haute, IN 47809 USA
期刊名称：BIOMED RESEARCH INTERNATIONAL （ 影响因子：3.411； 五年影响因子：3.62 ）
ISSN： 2314-6133
年卷期： 2016 年
页码：
收录情况： SCI
摘要： Genetic networks provide new mechanistic insights into the diversity of species morphology. In this study, we have integrated the MGI, GEO, and miRNA database to analyze the genetic regulatory networks under morphology difference of integument of humans and mice. We found that the gene expression network in the skin is highly divergent between human and mouse. The GO term of secretion was highly enriched, and this category was specific in human compared to mouse. These secretion genes might be involved in eccrine system evolution in human. In addition, total 62,637 miRNA binding target sites were predicted in human integument genes (IGs), while 26,280 miRNA binding target sites were predicted in mouse IGs. The interactions between miRNAs and IGs in human aremore complex than those inmouse. Furthermore, hsa-miR-548, mmu-miR-466, andmmu-miR-467 have an enormous number of targets on IGs, which both have the role of inhibition of host immunity response. The pattern of distribution on the chromosome of these three miRNAs families is very different. The interaction of miRNA/IGs has added the new dimension in traditional gene regulation networks of skin. Our results are generating new insights into the gene networks basis of skin difference between human and mouse.
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