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Whole-Genome Sequencing of Lactiplantibacillus plantarum YY-112 and Investigation of Its Immune-Modulating Abilities In Vivo

文献类型： 外文期刊

作者： Luo, Mengfan 1 ; Zhou, Wanyi 2 ; Tao, Wenyang 2 ; Xing, Jianrong 2 ; Li, Jingrui 2 ; Yang, Ying 2 ; Guo, Yuxing 1 ;

作者机构： 1.Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Dept Food Sci & Technol, Nanjing 210023, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Food Sci, Hangzhou 310021, Peoples R China

关键词： Lactiplantibacillus plantarum; genome; cyclophosphamide; immunity; intestinal microbiota

期刊名称：FERMENTATION-BASEL （ 影响因子：3.3； 五年影响因子：3.7 ）

ISSN：

年卷期： 2023 年 9 卷 12 期

页码：

收录情况： SCI

摘要： A potentially novel probiotic strain, YY-112, was previously isolated and identified as Lactiplantibacillus pentosus using 16S rDNA sequencing. The whole genome analysis showed that strain YY-112 has the potential to metabolize carbohydrates in the gastrointestinal environment and to regulate immunity. Further, comparative genomics analysis revealed that strain YY-112 was Lactiplantibacillus plantarum (L. plantarum) with more unique genes. The results of in vivo tests showed that L. plantarum YY-112 had no adverse effects and restored the damaged spleen and intestinal barrier of immunocompromised mice. L. plantarum YY-112 recovered the normal levels of lymphocytes, serum cytokines (Interferon-gamma, tumor necrosis factor alpha, and interleukin-6), immunoglobulins (Ig) (IgA, IgM, and IgG) and lipids (albumin, cholesterol, triglyceride). Additionally, L. plantarum YY-112 might indirectly enhance the immune system by improving the intestinal microbiota structure. These results supported the potential of L. plantarum YY-112 as a probiotic to regulate the immune system of hosts.

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