文献类型： 外文期刊
作者： Li, Dang-Dang 1 ; Guo, Chuan-Hui 1 ; Yue, Liang 2 ; Duan, Cui-Cui 3 ; Yang, Zhan-Qing 1 ; Cao, Hang 1 ; Guo, Bin 1 ; Yue, 1 ;
作者机构： 1.Jilin Univ, Coll Vet Med, Changchun 130023, Peoples R China
2.Jilin Univ, Coll Clin Med, Changchun 130023, Peoples R China
3.Jilin Acad Agr Sci, Inst Agrofood Technol, Changchun, Peoples R China
关键词： Hmgn3;Decidualization;Stromal cell;Uterus;Mouse
期刊名称：MOLECULAR AND CELLULAR ENDOCRINOLOGY （ 影响因子：4.102； 五年影响因子：4.226 ）
ISSN： 0303-7207
年卷期： 2015 年 413 卷 C 期
页码：
收录情况： SCI
摘要： Although Hmgn3 is involved in the regulation of development and cellular differentiation, its physiological roles on decidualization are still unknown. Here we showed that Hmgn3 was highly expressed in the decidua and decidualizing stromal cells. Overexpression of Hmgn3 variants, Hmgn3a or Hmgn3b, enhanced the expression of decidualization markers Prl8a2 and Prl3c1, whereas inhibition of Hmgn3 reduced their expression. Hmgn3 could mediate the effects of Hoxa10 and cAMP on the expression of Prl8a2 and Prl3c1. Further study found that Hmgn3 directed the process of decidualization through influencing the expression of Hand2. Progesterone could induce the expression of Hmgn3 in the ovariectomized mouse uterus, uterine epithelial cells and stromal cells. Knockdown of Hoxa10 with siRNA alleviated the induction of progesterone and cAMP on Hmgn3 expression. Simultaneously, siRNA-mediated down-regulation of Hmgn3 in the uterine stromal cells could attenuate the effects of progesterone, cAMP and Hoxa10 on the expression of Hand2. Collectively, Hmgn3 may play an important role during mouse decidualization. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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