您好，欢迎访问山西省农业科学院 机构知识库！
山西省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Effects of sulfur dioxide on expressions of p53, bax and bcl-2 in lungs of asthmatic rats

文献类型： 外文期刊

作者： Xie, Jingfang 1 ; Li, Ruijin 1 ; Fan, Renjun 3 ; Meng, Ziqiang 1 ;

作者机构： 1.Shanxi Univ, Inst Environm Med & Toxicol, Taiyuan 030006, Peoples R China

2.Shanxi Univ, Coll Environm & Resource, Taiyuan 030006, Peoples R China

3.Shanxi Acad Agr Sci, Inst Plant Protect, Taiyuan, Peoples R China

关键词： sulfur dioxide;asthmatic rats;lungs;bax;bcl-2;p53

期刊名称：INHALATION TOXICOLOGY （ 影响因子：2.724； 五年影响因子：2.55 ）

ISSN： 0895-8378

年卷期： 2009 年 21 卷 8-11 期

页码：

收录情况： SCI

摘要： Inhibition of cell apoptosis is an increasingly important factor in modulating airway inflammation in asthma, which is related to environmental pollutants. To investigate the effects of sulfur dioxide (SO2) on the mRNA and protein expressions of apoptosis-related genes in lungs from asthmatic rats, male Wistar rats were challenged by ovalbumin (OVA) or SO2 (2 ppm) inhalation alone or together. Examinations were performed 24 h after the last treatment. The mRNA and protein levels of p53, bax, and bcl-2 were analyzed in lungs using real-time reverse transcription-polymerase chain reaction (RTPCR) assay and Western blot analysis, respectively. The results indicated that increases of bcl-2 or decreases of p53 and bax mRNA and protein levels were not significant in lungs of rats exposed to SO2 alone, compared with controls, but elevated or reduced levels of these genes appeared in lungs of asthmatic rats exposed to SO2 plus OVA, compared with controls, suggesting that SO2 exposure could result in OVA-induced increases or decreases of transcription and translation levels of these apoptosis-related genes in rat lungs, and may have relations to airway inflammation in asthma. The regulation mechanism of apoptosis in asthma disease exposure to SO2 needs further study.

  • 相关文献

[1]Postharvest physiology, storage and transportation of litchi fruits - A review. Shi, JX,Wang, CS,An, XZ,Li, JH,Zhao, M. 2001

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：山西省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台