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The dynamic landscape of gene regulation during Bombyx mori oogenesis

文献类型： 外文期刊

作者： Zhang, Qiang 1 ; Sun, Wei 1 ; Sun, Bang-Yong 1 ; Xiao, Yang 2 ; Zhang, Ze 1 ;

作者机构： 1.Chongqing Univ, Sch Life Sci, Lab Evolutionary & Funct Genom, Chongqing 400044, Peoples R China

2.Guangdong Acad Agr Sci, Sericulture & Agrifood Res Inst, Guangzhou 510640, Guangdong, Peoples R China

3.Chongqing Univ, Sch Life Sci, Lab Evolutionary & Funct Genom, Chongqing 401331, Peoples R China

关键词： Bombyx mori;Oogenesis;Gene regulation;Ecdysteroid biosynthesis;Co-expression network;Transcription factors

期刊名称：BMC GENOMICS （ 影响因子：3.969； 五年影响因子：4.478 ）

ISSN： 1471-2164

年卷期： 2017 年 18 卷

页码：

收录情况： SCI

摘要： Background: Oogenesis in the domestic silkworm (Bombyx mori) is a complex process involving previtellogenesis, vitellogenesis and choriogenesis. During this process, follicles show drastic morphological and physiological changes. However, the genome-wide regulatory profiles of gene expression during oogenesis remain to be determined. Results: In this study, we obtained time-series transcriptome data and used these data to reveal the dynamic landscape of gene regulation during oogenesis. A total of 1932 genes were identified to be differentially expressed among different stages, most of which occurred during the transition from late vitellogenesis to early choriogenesis. Using weighted gene co-expression network analysis, we identified six stage-specific gene modules that correspond to multiple regulatory pathways. Strikingly, the biosynthesis pathway of the molting hormone 20-hydroxyecdysone (20E) was enriched in one of the modules. Further analysis showed that the ecdysteroid 20-hydroxylase gene (CYP314A1) of steroidgenesis genes was mainly expressed in previtellogenesis and early vitellogenesis. However, the 20E-inactivated genes, particularly the ecdysteroid 26-hydroxylase encoding gene (Cyp18a1), were highly expressed in late vitellogenesis. These distinct expression patterns between 20E synthesis and catabolism-related genes might ensure the rapid decline of the hormone titer at the transition point from vitellogenesis to choriogenesis. In addition, we compared landscapes of gene regulation between silkworm (Lepidoptera) and fruit fly (Diptera) oogeneses. Our results show that there is some consensus in the modules of gene co-expression during oogenesis in these insects. Conclusions: The data presented in this study provide new insights into the regulatory mechanisms underlying oogenesis in insects with polytrophic meroistic ovaries. The results also provide clues for further investigating the roles of epigenetic reconfiguration and circadian rhythm in insect oogenesis.

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