Recent Advances in the Preparation, Structure, and Biological Activities of beta-Glucan from Ganoderma Species: A Review
文献类型： 外文期刊
作者： Zhang, Henan 1 ; Zhang, Jingsong 1 ; Liu, Yanfang 1 ; Tang, Chuanhong 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Natl Engn Res Ctr Edible Fungi, Key Lab Edible Fungi Resources & Utilizat South,Mi, Shanghai 201403, Peoples R China
关键词： Ganoderma; beta-D-glucan; structural characteristics; bioactivity; application
期刊名称：FOODS （ 影响因子：5.2； 五年影响因子：5.5 ）
ISSN：
年卷期： 2023 年 12 卷 15 期
页码：
收录情况： SCI
摘要： Ganoderma has served as a valuable food supplement and medicinal ingredient with outstanding active compounds that are essential for human protection against chronic diseases. Modern pharmacology studies have proven that Ganoderma beta-D-glucan exhibits versatile biological activities, such as immunomodulatory, antitumor, antioxidant, and antiviral properties, as well as gut microbiota regulation. As a promising polysaccharide, beta-D-glucan is widely used in the prevention and treatment of various diseases. In recent years, the extraction, purification, structural characterization, and pharmacological activities of polysaccharides from the fruiting bodies, mycelia, spores, and fermentation broth of Ganoderma species have received wide attention from scholars globally. Unfortunately, comprehensive studies on the preparation, structure and bioactivity, toxicology, and utilization of beta-D-glucans from Ganoderma species still need to be further explored, which may result in limitations in future sustainable industrial applications of beta-D-glucans. Thus, this review summarizes the research progress in recent years on the physicochemical properties, structural characteristics, and bioactivity mechanisms of Ganoderma beta-D-glucan, as well as its toxicological assessment and applications. This review is intended to provide a theoretical basis and reference for the development and application of beta-D-glucan in the fields of pharmaceuticals, functional foods, and cosmetics.
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