Regulation network of serum cytokines induced by tuberculosis-specific antigens reveals biomarkers for tuberculosis diagnosis
文献类型： 外文期刊
作者： Wei, M. 1 ; Wu, Z. Y. 1 ; Lin, J. H. 1 ; Li, Y. 2 ; Qian, Z. X. 3 ; Xie, Y. Q. 1 ; Su, H. 1 ; Zhou, W. 1 ;
作者机构： 1.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangzhou, Guangdong, Peoples R China
2.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangzhou, Guangdong, Peoples R China
3.First Hosp Putian City, Dept Cardiothorac Surg, Putian, Peoples R China
关键词： Cytokine regulation network;Inflammatory cytokines;Interferon-gamma;Tuberculosis
期刊名称：GENETICS AND MOLECULAR RESEARCH （ 影响因子：0.764； 五年影响因子：0.912 ）
ISSN： 1676-5680
年卷期： 2015 年 14 卷 4 期
页码：
收录情况： SCI
摘要： In this study, we identified potential serum biomarkers for the diagnosis of active tuberculosis (TB) and screening for latent TB infections (LTBIs). Peripheral blood samples from 40 healthy individuals, 40 patients with TB, and 40 LTBI individuals were stimulated with the TB-specific antigens ESAT-6 and CFP-10. Human inflammatory cytokine arrays were used to detect the expression of inflammatory cytokines. Cytokines with significant changes were screened to construct a cytokine regulation network. The levels of the cytokines CCL1 (I-309), CXCL9 (MIG), IL-10, IL-6, CSF2, CSF3, IL-8, IL-1 alpha, IL-7, TGF-beta 1, CCL2, IL-2, IL-13, and TNF alpha were significantly upregulated in the active TB group. The levels of CCL3, IL-1 beta, CCL8, IFN gamma, and CXCL10 were significantly increased in the TB groups compared to those in the healthy control group. sTNF RII was upregulated in the LTBI group. CCL4 and MIP1d were significantly increased in all groups. The upregulated cytokines were mainly found in the IFN gamma and IL-1 alpha regulatory networks. Importantly, we found that CXCL10 (IP-10), CCL3, CCL8, and IL-1 beta may be more suitable than IFN. for active or latent TB infection screening. Furthermore, we found that levels of CCL1 (I-309), CXCL9 (MIG), IL-10, IL-6, CSF2, CSF3, IL-8, IL-1 alpha, IL-7, TGF-beta 1, CCL2, IL-2, and IL-13 after TB antigen stimulation may help distinguish between active and latent TB.
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