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Antimycins A(19) and A(20), two new antimycins produced by marine actinomycete Streptomyces antibioticus H74-18

文献类型： 外文期刊

作者： Xu, Lin-Ya 1 ; Quan, Xue-Sheng 1 ; Wang, Chen 2 ; Sheng, Hui-Fang 3 ; Zhou, Guang-Xiong 1 ; Lin, Bi-Run; Jiang, Ren 1 ;

作者机构： 1.Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

2.Guangdong Acad Agr Sci, Inst Plant Protect, Key Lab New Tech Plant Protect Guangdong, Guangzhou 510632, Guangdong, Peoples R China

3.Guangdong Acad Agr Sci, Inst Plant Protect, Key Lab New Tech Plant Protect Guangdong, Guangzhou 510632, Gua

关键词： actinomycete;antifungal activity;antimycins A(19) and A(20);Streptomyces antibioticus;X-ray diffraction

期刊名称：JOURNAL OF ANTIBIOTICS （ 影响因子：2.649； 五年影响因子：2.772 ）

ISSN： 0021-8820

年卷期： 2011 年 64 卷 10 期

页码：

收录情况： SCI

摘要： Two new antimycin antibiotics, that is antimycins A(19) (1) and A(20) (2), were isolated from a cultured broth of marine actinomycete Streptomyces antibioticus H74-18 together with antimycins A(1a) (3a) and A(1b) (3b), A(2a) (4), A(3a) (5a) and A(3b) (5b). Their structures were determined by spectroscopic methods in combination with X-ray diffraction. Antimycin A(19) possessed a chiral acyl chain and an alkyl branch. The absolute configuration of chiral acyl chain in 1 was determined by X-ray diffraction analysis. Antimycin A(20) (2) has the shortest and simplest acetoxy acyl chain in the antimycins family. All the antimycins (1-5) showed potential antifungal activities against Candida albicans with MIC of about 5-10 mu g ml(-1). The Journal of Antibiotics (2011) 64, 661-665; doi:10.1038/ja.2011.65; published online 17 August 2011

  • 相关文献

[1]Kitamycin C, a new antimycin-type antibiotic from Streptomyces antibioticus strain 200-09. Wang, Fan,Fu, Shu-Na,Bao, Yi-Xuan,Yang, Yu,Zhou, Guang-Xiong,Shen, Hui-Fang,Lin, Bi-Run. 2017

[2]Neoantimycins A and B, Two Unusual Benzamido Nine-Membered Dilactones from Marine-Derived Streptomyces antibioticus H12-15. Hu, Chen,Zhou, Shi-Wen,Chen, Fang,Zheng, Xin-Heng,Zhou, Guang-Xiong,Shen, Hui-Fang,Lin, Bi-Run.

[3]A new fungicide produced by a Streptomyces sp GAAS7310. Chen, GY,Lin, BR,Lin, YC,Xie, FC,Lu, W,Fong, WF. 2005

[4]Antifungal Activities of Crude Extractum from Camellia semiserrata Chi (Nanshancha) Seed Cake Against Colletotrichum musae, Colletotrichum gloeosporioides and Penicillium italicum in vitro and in vivo Fruit Test. Meng, Xiangchun,Li, Jun,Bi, Fangcheng,Zhu, Lixue,Ma, Zhiyu. 2015

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