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A new secondary metabolite from the fermented mycelia of Streptomyces antibiotic H41-55

文献类型： 外文期刊

作者： Li, Xian-Sheng 1 ; Zheng, Xin-Heng 1 ; Chen, Fang 1 ; Lin, Bi-Run 2 ; Zhou, Guang-Xiong 1 ;

作者机构： 1.Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China

2.Guangdong Acad Agr Sci, Inst Plant Protect, Key Lab New Tech Plant Protect Guangdong, Guangzhou 510110, Guangdong, Peoples R China

关键词： Streptomyces antibiotic; strain identification; streptomyceamide D; cytotoxicity; antifungal activity

期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）

ISSN： 1028-6020

年卷期： 2018 年 20 卷 8 期

页码：

收录情况： SCI

摘要： An actinomycete strain, H41-55 from sea sediment was identified as Streptomyces antibiotic on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA data. A new secondary metabolite, (2S,3R)-N-[3-(formylamino)-2-hydroxybenzoyl]-l-threonine propyl ester (1), together with five known compounds was isolated from fermentation product by use of silica gel and Sephadex LH-20 column chromatography, and preparative RP-C18 HPLC, and identified by HR-TOF-MS and NMR spectra. The cytotoxicities of these isolates against three cancer cell lines and their antifungal activities on Candida albicans were tested. Compounds 1, 3, 5, and 6 displayed moderate cytotoxicity. 5 and 6 showed inhibitory activity on C. albicans. [GRAPHICS] .

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