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Ergosterols from the Culture Broth of Marine Streptomyces anandii H41-59

文献类型： 外文期刊

作者： Zhang, Yang-Mei 1 ; Li, Hong-Yu 1 ; Hu, Chen 1 ; Sheng, Hui-Fan 2 ; Zhang, Ying 1 ; Lin, Bi-Run 2 ; Zhou, Guang-Xiong 1 ;

作者机构： 1.Jinan Univ, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China

2.Guangdong Acad Agr Sci, Inst Plant Protect, Guangzhou 510632, Guangdong, Peoples R China

关键词： Streptomyces anandii;ergosterols;strain identification;ananstreps A-C;cytotoxicity

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2016 年 14 卷 5 期

页码：

收录情况： SCI

摘要： An actinomycete strain, H41-59, isolated from sea sediment in a mangrove district, was identified as Streptomyces anandii on the basis of 16S rDNA gene sequence analysis as well as the investigation of its morphological, physiological and biochemical characteristics. Three new ergosterols, ananstreps A-C (1-3), along with ten known ones (4-13), were isolated from the culture broth of this strain. The gross structures of these new compounds were elucidated on the basis of extensive analysis of spectroscopic data, including HR-ESI-MS, and NMR. The cytotoxicities of these isolates against human breast adenocarcinoma cell line MCF-7, human glioblastoma cell line SF-268, and human lung cancer cell line NCI-H460 and their antibacterial activities in inhibiting the growth of Candida albicans and some other pathogenic microorganisms were tested. Compounds 3-8, 10 and 11 displayed cytotoxicity with IC50 values in a range from 13.0 to 27.8 g/mL. However, all the tested compounds showed no activity on C. albicans and other bacteria at the test concentration of 1 mg/mL with the paper disc diffusion method.

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[1]Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59. Zhang, Yang-Mei,Liu, Bai-Lian,Zheng, Xin-Heng,Huang, Xiao-Jun,Li, Hong-Yu,Zhang, Ying,Zhang, Ting-Ting,Zhou, Guang-Xiong,Sun, Da-Yuan,Lin, Bi-Run. 2017

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